Marcelo Fernandes da Silva

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A shift in the activation of pulmonary macrophages characterized by an increase of IL-1, TNF-α and IL-6 production has been induced in mice infected with Paracoccidioides brasiliensis. It is still unclear whether a functional shift in the resident alveolar macrophage population would be responsible for these observations due to the expression of cell(More)
The antibody response against the antigen sheep red blood cells (SRBC) was investigated in mice pre-treated with formalin-killedParacoccidioides brasiliensis or with cell wall fractions of the fungus. Pre-treatment withP. brasiliensis, as well as with the F1 fraction and beta-glucan significantly increased the anti-SRBC antibody response in the experimental(More)
Pulmonary macrophages (PM), which are CD11b/CD18+ and CD23+, may be involved in the onset of inflammatory events caused by Paracoccidioides brasiliensis in the lungs. In the present study, we measured the nitric oxide (NO) and interleukin in PM production after intratracheal (i.t.) inoculation of an enriched β-glucan cell wall fraction from P. brasiliensis(More)
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