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Accumulating evidence suggest a life-long impact of disease related mechanisms on brain structure in schizophrenia which may be modified by antipsychotic treatment. The aim of the present study was to investigate in a large sample of patients with schizophrenia the effect of illness duration and antipsychotic treatment on brain structure. Seventy-one(More)
The paper propses a new shape morphometry approach that combines advanced classification techniques with geometric features to identify morphological abnormalities on the brain surface. Our aim is to improve the classification accuracy in distinguishing between normal subjects and schizophrenic patients. The approach is inspired by natural language(More)
In this paper a novel approach to schizophrenia classification using magnetic resonance images (MRI) is proposed. The presented method is based on dissimilarity based classification techniques applied to morphological MRIs and diffusion weighted images (DWI). Instead of working with features directly, pairwise dissimilarities between expert * Corresponding(More)
In this paper, we exploit spectral shape analysis techniques to detect brain morphological abnormalities. We propose a new shape descriptor able to encode morphometric properties of a brain image or region using diffusion geometry techniques based on the local Heat Kernel. Using this approach, it is possible to design a versatile signature, employed in this(More)
Structural and functional studies have shown that schizophrenia is often associated with frontolimbic abnormalities in the prefrontal and mediotemporal regions. It is still unclear, however, if such dysfunctional interaction extends as well to relay regions such as the thalamus and the anterior insula. Here, we measured gray matter volumes of five(More)
BACKGROUND The entorhinal cortex is located in the medial temporal lobe and is involved in memory and learning. Previous MRI studies reported conflicting findings in schizophrenia, showing normal or reduced entorhinal size. OBJECTIVES To explore entorhinal cortex volumes in a large sample of patients with schizophrenia recruited from the geographically(More)
BACKGROUND Diffusion tensor imaging allows the study of integrity of white matter (WM) tracts. Literature suggests that WM integrity could be altered in bipolar disorder. Heterogeneity of brain imaging methods, the studied samples, and drug treatments make localization, nature, and severity of the WM abnormalities unclear. METHODS We applied tract-based(More)
Although the pathogenesis of bipolar disorder is still not completely understood, there is evidence from imaging studies that abnormalities in inter-hemispheric communication may play a major role in the pathophysiology of bipolar disorder. In the present review, we discuss the most consistent findings from diffusion imaging studies exploring corpus(More)
Brain atrophy has consistently been observed in schizophrenia, representing a 'gross' evidence of anatomical abnormalities. Reduced cerebral blood volume (CBV) may accompany brain size decrement in schizophrenia, as suggested by prior small SPECT studies. In this study, we non-invasively investigated the hemisphere CBV in a large sample of patients(More)