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A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
STUDY OBJECTIVES To investigate the link between extreme diurnal preference, delayed sleep phase syndrome, and a length polymorphism in Per3. DESIGN Subjects were genotyped using polymerase chainExpand
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A single-nucleotide polymorphism in the 5'-untranslated region of the hPER2 gene is associated with diurnal preference.
The PERIOD2 (PER2) gene is a key component of the molecular mechanism that generates circadian rhythms in mammals. A missense mutation in the human PER2 gene has previously been linked to advancedExpand
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Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulphatoxymelatonin (aMT6S) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, theExpand
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Melatonin in mood disorders
The cyclic nature of depressive illness, the diurnal variations in its symptomatology and the existence of disturbed sleep–wake and core body temperature rhythms, all suggest that dysfunction of theExpand
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Current role of melatonin in pediatric neurology: clinical recommendations.
BACKGROUND/PURPOSE Melatonin, an indoleamine secreted by the pineal gland, plays a key role in regulating circadian rhythm. It has chronobiotic, antioxidant, anti-inflammatory and free radicalExpand
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A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans
AbstractThe three PERIOD proteins form a major negative feedback component of the molecular mechanism governing the periodicity of the vertebrate circadian clock. Genetic variations within the humanExpand
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An unusual neurological consequence of massive wasp stings
Although rare, central and peripheral neurological manifestations after single or multiple wasp stings have been reported. The authors describe a 45-year-old man who developed periods of sudden lossExpand
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Proteomic study on the stability of proteins in bovine, camel, and caprine milk sera after processing
Abstract Milk proteins have been shown to be very sensitive to processing. This study aims to investigate the changes of the bovine, camel, and caprine milk proteins after freezing, pasteurizationExpand
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Melatonin in Circadian Rhythm Sleep Disorders
Normal circadian rhythms are synchronized to a regular 24 hr environmental light/dark (L/D) cycle. Both suprachiasmatic nucleus (SCN) and melatonin are essential for this adaptation.Expand
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