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Amphetamine decreases behavioral inhibition by stimulation of dopamine D2, but not D3, receptors
Behavioral disinhibition is a manifestation of impulsive behavior that is prominent in the psychopathology of various psychiatric disorders such as addiction, attention-deficit hyperactivityExpand
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Affective communication in rodents: serotonin and its modulating role in ultrasonic vocalizations
Serotonin (5-hydroxytryptamine, 5-HT) is an important modulatory neurotransmitter and functions as a key neurodevelopmental signal in the mammalian brain. 5-HT plays a prominent role in regulatingExpand
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5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement.
Re-exposure to drug-related cues elicits drug-seeking behaviour and relapse in humans even after months of abstinence. Similarly, in laboratory rats, drug-associated stimuli reinstate cocaine seekingExpand
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Antidepressant treatment in anxiety disorders.
Antidepressant drug treatment is the clinical standard of care for all types of anxiety disorders. Broad efficacy of selective serotonin reuptake inhibitors suggests the importance of enhancedExpand
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Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists.
Herein we report the discovery of a novel oxindole-based series of vasopressin 1b (V1b) receptor antagonists. Introducing a substituted piperazine moiety and optimizing the southern and the northernExpand