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A new class of synthetic peptide inhibitors blocks attachment and entry of human pathogenic viruses.
Many enveloped viruses, including herpes viruses, hepatitis B virus (HBV), and hepatitis C virus (HCV), and human immunodeficiency virus (HIV), are among the most important human pathogens and areExpand
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Formation of Trans-Activation Competent HIV-1 Rev:RRE Complexes Requires the Recruitment of Multiple Protein Activation Domains
The HIV-1 Rev trans-activator is a nucleocytoplasmic shuttle protein that is essential for virus replication. Rev directly binds to unspliced and incompletely spliced viral RNA via the cis-acting RevExpand
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Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.
Aaptamine is a marine compound isolated from the sponge Aaptos aaptos showing antiproliferative properties via an undefined mode of action. We analyzed the effects of aaptamine treatment on theExpand
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Linker‐Region Modified Derivatives of the Deoxyhypusine Synthase Inhibitor CNI‐1493 Suppress HIV‐1 Replication
The inhibition of cellular factors that are involved in viral replication may be an important alternative to the commonly used strategy of targeting viral enzymes. The guanylhydrazone CNI‐1493, aExpand
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Excision of HIV-1 Proviral DNA by Recombinant Cell Permeable Tre-Recombinase
Over the previous years, comprehensive studies on antiretroviral drugs resulted in the successful introduction of highly active antiretroviral therapy (HAART) into clinical practice for treatment ofExpand
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In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway
BackgroundDeoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum. Target evaluation of parasitic DHS hasExpand
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In silico Design, Synthesis, and Screening of Novel Deoxyhypusine Synthase Inhibitors Targeting HIV‐1 Replication
The human enzyme deoxyhypusine synthase (DHS) is an important host cell factor that participates in the post‐translational hypusine modification of eukaryotic initiation factor 5A (eIF‐5A).Expand
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Rational Drug Design—Screening and Synthesis of Potential Deoxyhypusine Synthase Inhibitors Targeting HIV-1 Replication
Cyclotriazadisulfonamide (CADA) inhibits HIV replication by pecifically down-modulating expression of the of the CD4 receptor rotein on host cells. Many analogs of CADA have been synthesized n orderExpand