Marcel Ander

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Repair of DNA breaks by single-strand annealing (SSA) is a major mechanism for the maintenance of genomic integrity. SSA is promoted by proteins (single-strand-annealing proteins [SSAPs]), such as eukaryotic RAD52 and λ phage Redβ. These proteins use a short single-stranded region to find sequence identity and initiate homologous recombination. However, it(More)
Optical traps are used to measure force (F) over a wide range (0.01 to 1,000 pN). Variations in bead radius (r) hinder force precision since trap stiffness (k trap) varies as r 3 when r is small. Prior work has shown k trap is maximized when r is approximately equal to the beam waist (w 0), which on our instrument was ~400 nm when trapping with a 1064-nm(More)
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