Marc de Perrot

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Ischemia–reperfusion–induced lung injury is characterized by nondiseases. The last decade has been marked by both a significant specific alveolar damage, lung edema, and hypoxemia occurring increase in the number of centers performing lung transplantawithin 72 hours after lung transplantation. The most severe form tion and in the number of recipients on the(More)
To assess the influence of recipient's and donor's factors as well as surgical events on the occurrence of reperfusion injury after lung transplantation. Retrospective study in the surgical intensive care unit (ICU) of a university hospital. We collected data on 60 lung transplantation donor/recipient pairs from June 1993 to May 2001, and compared the(More)
Cancer immunotherapy has shown promising results when combined with chemotherapy. Blocking CTLA-4 signaling by monoclonal antibody between cycles of chemotherapy may inhibit cancer cell repopulation and enhance the antitumoral immune reaction, thus improve the efficacy of chemotherapy in mesothelioma. The impact of CTLA-4 blockade on the early stage of(More)
Malignant pleural mesothelioma is an aggressive disease that continues to be associated with poor outcomes. Although, traditionally this disease is considered to be resistant to radiotherapy, more recent evidence suggests that radiotherapy can produce positive outcomes. Over the past 15 years, the development of new, highly conformal radiotherapy(More)
there are limited treatment options for malignant pleural mesothelioma. Cisplatin-based chemotherapy has shown some survival benefit, but results remain discouraging. Radiation has been used as a palliative measure. Recent attempts to improve the effect of radiation with surgical resection have shown some promise. At the 8 annual Ontario Thoracic Cancer(More)
We studied the impact of natural killer T (NKT) cell activation by alpha-galactocysylceramide (α-GalCer, α-GC) on cancer cell repopulation during chemotherapy in murine mesothelioma. The number of NKT cells was found to be increased during the development of murine mesothelioma. NKT cells specifically recognize α-GC through CD1d resulting in their(More)
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