Marc W. Haut

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OBJECTIVES The primary aim of this pilot investigation was to identify structural brain differences in older adults with chronic low back pain (CLBP) as compared with pain-free individuals. DESIGN Cross-sectional, case-control. PARTICIPANTS Sixteen cognitively intact older adults, eight with CLBP and eight pain-free; excluded if with psychiatric or(More)
PURPOSE The purpose of this study was to examine the effect of adjuvant chemotherapy on normal-appearing white matter in women with breast cancer. PATIENTS AND METHODS Ten patients with early-stage breast cancer who were treated with adjuvant chemotherapy and 9 age-, education-, and IQ-matched healthy controls were studied with magnetic resonance imaging.(More)
Performance on the Wisconsin Card Sorting Test (WCST) is widely reported to be impaired in patients with schizophrenia. It has been hypothesized that the performance deficit on the WCST in schizophrenia is related to a dysfunction of the frontal lobe, specifically the dorsolateral prefrontal cortex. This hypothesis was tested by comparing a group of(More)
BACKGROUND AND PURPOSE To our knowledge, no published studies have examined whole-brain regional differences to identify more discrete volumetric changes in the brains of childhood leukemia survivors. We used voxel-based morphometry (VBM) to examine regional gray and white matter differences in a group of long-term survivors of acute lymphoblastic leukemia(More)
Closed head injury (CHI) results in significant memory dysfunction. Although the disabling aspects of memory impairment after CHI have been recognized, little attention has been focused on the theoretical nature of these memory problems. A means of examining semantic sensitivity to the importance of the ideas presented in the Wechsler Memory Scale-Revised(More)
Although several scales have been developed to assess burden, their clinical utility has been limited by the absence of relevant cutoff points. Clinical data from 140 primary caregivers seeking a dementia evaluation for a family member were analyzed to establish the psychometric properties of a caregiver burden screen. Results indicate that the cutoff(More)
Recent advances in neuroimaging have enabled researchers to establish relatively specific areas of the brain that are involved in working memory. In this positron emission tomography study we examined the pattern of neural activation associated with performance on number-letter sequencing, a purported measure of working memory included in the new Wechsler(More)
OBJECTIVE Changes to cognition and behavior have been reported after long-term exposure to solvents. Solvents are hypothesized to affect brain white matter. To test this, we examined the volume of the corpus callosum in workers with a history of exposure to solvents. METHODS We manually traced (blind to group membership) the volume of the corpus callosum(More)
The existence of a rostrocaudal gradient of medial temporal lobe (MTL) activation during memory encoding has historically received support from positron emission tomography studies, but less so from functional MRI (FMRI) studies. More recently, FMRI studies have demonstrated that characteristics of the stimuli can affect the location of activation seen in(More)
Neuropsychological studies have documented frontal dysfunction in patients with a history of exposure to organic solvents. The deficits typically observed in these patients appear to be related to working memory (WM). This study used [15O] water positron emission tomography (PET) to examine the pattern of neural activation during verbal working memory in(More)