Marc Tonnellier

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OBJECTIVE To assess the predictive capacity for the diagnosis of ventilator-associated pneumonia (VAP) of serum procalcitonin levels before and on the day it is suspected. DESIGN AND SETTING Single-center observational study in the intensive care unit of a teaching hospital. PATIENTS AND PARTICIPANTS Consecutive patients whose serum procalcitonin levels(More)
OBJECTIVE To assess the cardiac consequences of successful respiratory weaning using the variations of circulating B-type and atrial natriuretic peptides (BNP, ANP) and Doppler mitral flow. DESIGN A prospective preliminary observational study. SETTING A 14-bed medical ICU in a French university hospital. PATIENTS Thirty-one patients undergoing a(More)
INTRODUCTION Air-space enlargement may result from mechanical ventilation and/or lung infection. The aim of this study was to assess how mechanical ventilation and lung infection influence the genesis of bronchiolar and alveolar distention. METHODS Four groups of piglets were studied: non-ventilated-non-inoculated (controls, n = 5),(More)
BACKGROUND Lung deposition of intravenous cephalosporins is low. The lung deposition of equivalent doses of ceftazidime administered either intravenously or by ultrasonic nebulization using either nitrogen-oxygen or helium-oxygen as the carrying gas of the aerosol was compared in ventilated piglets with and without experimental bronchopneumonia. METHODS(More)
OBJECTIVE To document the prevalence of respiratory virus infections in patients with chronic cardiac or pulmonary disorders admitted to a critical care unit for acute cardiorespiratory failure. DESIGN, SETTING, PATIENTS The study took place in a critical care unit during two consecutive winters. All patients admitted to the unit for acute respiratory or(More)
OBJECTIVE We examined whether invasive lung-specimen collection-to-treatment times for intensive care unit patients with suspected ventilator-associated pneumonia (VAP) differ with to the work shift during which specimens were collected. We compared weekday day shifts and off-hours (from 6:30 p.m. to 8:29 a.m. the next day for night shifts, from Saturday(More)
INTRODUCTION Enterococci are frequently responsible for endocarditis, but a rare cause of meningitis. OBSERVATION A 55 years-old man presented with Enterococcus faecium meningitis. Systematic transoesophageal echocardiography (TOE), despite the absence of organic murmur and the negativity of the hemocultures, revealed a concomitant aortic endocarditis. (More)
OBJECTIVE Lung tissue deposition of intravenous ceftazidime administered either continuously or intermittently was compared in ventilated piglets with experimental bronchopneumonia. DESIGN Prospective experimental study ANIMALS Eighteen anesthetized and ventilated piglets INTERVENTIONS Bronchopneumonia was produced by the intrabronchial inoculation of(More)