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Addiction can be considered as a form of neuronal adaptation within the reward circuitry. Upon psychostimulant administration, long-term behavioral adaptations are associated with synaptic plasticity and morphological changes of medium spiny neurons (MSN) from the striatum. Increased spine density onto MSN in response to chronic cocaine exposure in mice has(More)
Recently there has been an increasing trend to use deep learning frameworks for both 2D consumer images and for 3D medical images. However, there has been little effort to use deep frameworks for volumetric vascular segmen-tation. We wanted to address this by providing a freely available dataset of 12 annotated two-photon vasculature microscopy stacks. We(More)
BACKGROUND Addiction relies on persistent alterations of neuronal properties, which depends on gene regulation. Activity-regulated cytoskeleton-associated protein (Arc) is an immediate early gene that modulates neuronal plasticity underlying learning and memory. Its role in cocaine-induced neuronal and behavioral adaptations remains elusive. METHODS Acute(More)
Securing individual data objects using sticky policies in trusted networks is essential in user centric distributing computing applications. However aggregation of data objects presents a challenge in terms of sticky policy integrity for the new object. A possible solution is based on a mathematical merger of sticky polices associated with all aggregated(More)
BACKGROUND Repeated cocaine exposure produces new spine formation in striatal projection neurons (SPNs) of the nucleus accumbens. However, an acute exposure to cocaine can trigger long-lasting synaptic plasticity in SPNs leading to behavioral alterations. This raises the intriguing question as to whether a single administration of cocaine could enduringly(More)
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