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The development of cochlear implantation has allowed the majority of patients deafened after the development of language to regain significant auditory benefit. In a subset of patients, however, loss of hearing results from destruction of the cochlear nerves, rendering cochlear implantation ineffective. The most common cause of bilateral destruction of the(More)
BACKGROUND Developing methods for protecting organisms in metal-polluted environments is contingent upon our understanding of cellular detoxification mechanisms. In this regard, half-molecule ATP-binding cassette (ABC) transporters of the HMT-1 subfamily are required for cadmium (Cd) detoxification. HMTs have conserved structural architecture that(More)
Screening a library of drugs with known safety profiles in humans yielded 30 drugs that reliably protected mammalian neurons against glucose toxicity. Subsequent screening demonstrated that 6 of these 30 drugs increase lifespan in C. elegans: caffeine, ciclopirox olamine, tannic acid, acetaminophen, bacitracin, and baicalein. Every drug significantly(More)
CONTEXT Successful outcome of complex surgical techniques depend on the surgical team's level of experience. However, unless benefit is demonstrated in the presence of cost savings, insurance companies are reluctant to approve care from highly experienced hospitals and surgical teams. OBJECTIVE To determine the relationship between the number of acoustic(More)
OBJECTIVES Determine if the presence of cerebrospinal fluid in the fundal region of the internal auditory canal on preoperative magnetic resonance imaging (MRI) scans is predictive of improved hearing preservation after removal of vestibular schwannoma through the middle cranial fossa approach. Relationships between fundal fluid, tumor nerve of origin,(More)
OBJECTIVE To assess the duration of hearing preservation from time of vestibular schwannoma middle fossa decompression with short-term and 1-year hearing preservation rates. STUDY DESIGN Retrospective case review. SETTING Tertiary referral center. PATIENTS Patients with and without neurofibromatosis type 2 who underwent middle fossa decompression. We(More)
Neurofibromatosis type 2 (NF 2) typically results in deafness due to disruption of the cochlear nerves, making peripheral devices such as cochlear implants ineffective. Auditory brainstem implants (ABIs), for direct electrical stimulation of the cochlear nucleus, have been used to provide auditory stimulation in this group of patients. Currently, 141(More)
OBJECTIVE To describe the case of a true false-positive finding on magnetic resonance imaging, mimicking a vestibular schwannoma, and review the pertinent literature. PATIENTS The case of a single patient with a suspicion of a vestibular schwannoma. INTERVENTION A middle fossa craniotomy was performed for resection of the presumed schwannoma. MAIN(More)
OBJECTIVES To examine hearing preservation rates, facial nerve outcomes, and tumor recurrence rates in patients with neurofibromatosis Type 2 undergoing a primary middle cranial fossa approach for vestibular schwannoma removal. STUDY DESIGN Retrospective chart review. SETTING Private practice tertiary neurotology referral center. PATIENTS All patients(More)
OBJECTIVE To determine whether partial tumor removal in large vestibular schwannoma improves facial nerve outcomes while maintaining a low risk of tumor regrowth/recurrence. STUDY DESIGN Retrospective chart review and prospective database. SETTING Tertiary neurotologic referral center. PATIENTS Four hundred patients with a vestibular schwannoma of 2.5(More)