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5-Azacytidine (5-AZA), a DNA methyl transferase inhibitor, is a clinically used epigenetic drug for cancer therapy. Recently, we have shown that 5-AZA upregulates ten-eleven translocation (TET) protein expression in hepatocellular carcinoma (HCC) cells, which induce active demethylation. Vitamin C facilitates TET activity and enhances active demethylation.(More)
Evaluation of the spoken and written language skills of prelingually deaf pupils is necessary to improve existing language curricula. Research on written language shows notable delays and substantial differences in the development of written language in comparison to hearing peers. It is difficult to investigate the spontaneous speech because of(More)
  • M Ruoss
  • 1997
Research on pain-related cognitions has up to now predominantly relied upon introspective questionnaire data. Experimental cognitive psychology offers an alternative way of access to the cognitive aspects of chronical pain. Building on the assumption that information-processing is in part uncontrolled, automatic and pre-attentive, similar processes are also(More)
This article reviews the empirical research which has examined the relationships among chronic pain and cognitions like attributions, coping, beliefs, expectations and problem solving. Methods for the examination of pain cognitions and coping strategies are reviewed. Current research which shows the significance of cognitions and coping for the(More)
  • M Ruoss
  • 1993
In previous experiments our group has shown that test subjects with normal hearing are able to draw pertinent information from visual signals generated from the analysis and transformation of speech. However, the results of these tests could be applied indiscriminately to the deaf. More recently we have studied the speed with which deaf subjects could learn(More)
BACKGROUND In a cognitive perspective, chronic pain comprises at least three dimensions: First it is possible to study the relevance of pain related attitudes, beliefs and coping cognitions for the chronification of pain. Second psychological processes of learning and memory processes can be analysed. Third we can investigate uncontrolled cognitions in(More)
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