Marc Revermann

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We aimed at comparing the effects of intravenous (i.v.) and inhaled (inh.) levosimendan (LEVO) on survival, inflammatory cytokines and the apoptotic mediator caspase-3 in a rat model of severe sepsis induced by cecal ligation and incision (CLI). Twenty-eight anesthetized/ventilated male Sprague–Dawley rats (body weight 528 ± 20 g) underwent laparotomy.(More)
OBJECTIVES The soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active dihydroxy derivatives. Because EETs have antiinflammatory properties, we determined whether or not inhibition of sEH attenuates disease development in the monocrotaline model of pulmonary hypertension in rats. METHODS sEH inhibition was(More)
Epoxyeicosatrienoic acids (EETs) build a family consisting of four arachidonic acid derived regioisomers that are generated by P450 epoxygenases. In the past years, growing interest in influencing EET level arose since EETs possess numerous beneficial effects in the cardiovascular system, for example, vasodilation, anti-inflammation and elicit renal and(More)
The suprachiasmatic nucleus (SCN) contains the primary mammalian circadian clock. This clock is entrained to environmental rhythms by external stimuli called zeitgebers. This entrainment is accomplished by the activation of specific, interacting signal transduction cascades. Since a cyclic guanosine monophosphate-dependent mechanism play a crucial(More)
The calcium-sensitizing drug levosimendan increases myocardial contractility and, by activating K+-channels, dilates pulmonary vessels. In the acute setting, levosimendan is clinically used to treat right heart failure in pulmonary hypertension. As K+-channel activation elicits several beneficial effects in the vascular system, we hypothesized that(More)
Formation of abdominal aortic aneurysms is a progressive inflammatory process that involves infiltration and differentiation of monocytes in the vessel wall, proliferation and migration of smooth muscle cells, and eventually the degradation of the internal elastic lamina, which leads to outward vascular remodeling and distension of the vessel. Because(More)
OBJECTIVE Epoxyeicosatrienoic acids (EETs) have antiinflammatory effects and are required for normal endothelial function. The soluble epoxide hydrolase (sEH) metabolizes EETs to their less active diols. We hypothesized that knockout and inhibition of sEH prevents neointima formation in hyperlipidemic ApoE(-/-) mice. METHODS AND RESULTS Inhibition of sEH(More)
Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation We thank Dr Tsuda1 for the important remark and his interest in our work. Unfortunately, we did not perform measurements on the effect of diltiazem on sympathetic nerve activity in our study and as mechanism of action of the drug we observed some direct inhibitory action(More)
BACKGROUND Right heart failure is a fatal consequence of chronic pulmonary hypertension (PH). The development of PH is characterized by increased proliferation of vascular cells, in particular pulmonary artery smooth muscle cells (PASMCs) and pulmonary artery endothelial cells. In the course of PH, an escalated right ventricular (RV) afterload occurs, which(More)