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BACKGROUND The purpose of this study was to determine the natural history of anastomotic leakage after elective colorectal resection and supraperitoneal anastomosis without temporary stoma. STUDY DESIGN Medical records from 1990 to 1997 were studied; 655 consecutive patients underwent colonic or rectal resection (without stoma). Patients were divided into(More)
The aim of this study was to determine by univariate and multivariate analyses the factors associated with clinically significant anastomotic leakage (AL) after large bowel resection. From 1990 to 1997 a series of 707 patients underwent colonic or rectal resection (without a stoma). Patients were divided into two groups: those with clinical anastomotic(More)
PURPOSE This study was designed to assess predictive factors of postoperative intra-abdominal septic complication in a homogenous group of patients undergoing ileocecal resection for Crohn's disease. METHODS From 1984 to 2004, 161 consecutive patients with Crohn's disease (81 males; mean age, 33 +/- 10 years) underwent, as a first operation, an elective(More)
PURPOSE The purpose of this study was to retrospectively compare the respective sensitivities of diffusion-weighted (DW), T2-weighted fast spin-echo (T2WFSE) and gadolinium chelate-enhanced MR imaging in the preoperative detection of hepatic metastases using intraoperative ultrasonographic and histopathologic findings as the standard of reference. (More)
PURPOSE The purpose of this study was to determine whether preoperative radiotherapy had an influence on the urinary and sexual function of patients having a sphincter-saving, nerve-preserving total mesorectal excision. METHODS Urinary and sexual function of male patients undergoing sphincter-saving, nerve-preserving total mesorectal excision for primary(More)
Obtaining representative human colon cancer cell lines from fresh tumors is technically difficult. Using 32 tumor fragments from patients with colon cancer, the present study shows that prior xenograft leads to more efficient cell line establishment compared with direct establishment from fresh tumors (P < 0.05). From 26 tumor specimens, we successfully(More)
OBJECTIVE To report a large number of patients with peritoneal carcinomatosis (PC) treated with complete cytoreductive (CCR-0) plus intraperitoneal chemotherapy, and to compare the results according to the origin of the primary: colon, rectum, small bowel, and appendix (excluding peritoneal pseudomyxoma). PATIENTS AND METHODS Among 615 patients treated(More)
HYPOTHESIS Stage I or II colorectal carcinomas with microsatellite instability (MSI) are characterized by more isolated lymph nodes in the resected specimen than their counterparts with microsatellite stability (MSS). DESIGN Prospective study. SETTING Academic research. PATIENTS Using a pentaplex polymerase chain reaction assay, MSI status was(More)
BACKGROUND Extrahepatic disease has always been considered an absolute contraindication to hepatectomy for liver metastases. The present study reports the long-term outcome and prognostic factors of patients undergoing resection of extrahepatic disease simultaneously with hepatectomy for liver metastases. METHODS From January 1987 to January 2001, 111 (30(More)
BACKGROUND Results and indications of intra-operative radiofrequency (RF) ablation of liver metastases (LM) are not well defined in the literature. AIM To appreciate the survival rate of patients with strictly unresectable LM (defined on technical but not oncological criteria) when undergoing liver resection plus RF, along with optimal systemic(More)