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Pretreatment by L-buthionine sulfoximine (BSO), which inactivates gamma-glutamylcysteine synthetase and, therefore, inhibits glutathione (GSH) synthesis, greatly increased the sensitivity of tumor cells to the antiproliferative effects of several NO-donating compounds. The sensitization that resulted from depletion of cellular GSH pools was observed in(More)
The organophosphorus nerve agents soman and tabun were tested in the hen at doses 120–150 times higher than their acute LD50, as it was assumed that these doses would produce delayed neuropathy. The animals were protected against the acute lethal effect of these agents by pretreatment with atropine, physostigmine, diazepam, and the oxime HI-6 or obidoxime.(More)
The anatomical and light microscopical structures of the pelvic urethra with the surrounding prostate were investigated in male pigs, which were castrated early in life and examined at slaughter weight. The general structure was regular in the caudal part, but was irregular in the cranial part. In the prostate each lobule contained a cell-rich stroma, which(More)
REASONS FOR PERFORMING STUDY Injuries of the equine stifle are frequent causes of hindlimb lameness. Ultrasonography is useful for the diagnosis of many soft tissue lesions but, until recently, its application to the equine stifle has been limited to a description of normal and abnormal structures. A comparative study using gross anatomical sections to(More)
The light-microscopical and ultrastructural differentiation of the disseminate prostate was studied in 12 boars and 8 barrows, ranging in age from 8 to 28 and 12 to 27 weeks, respectively. The barrows had been castrated at the age of 8 weeks. In young boars the prostate is organized in an inner zone and an outer zone. The glandular tubules of the latter are(More)
The diffuse infiltration by plasma cells in the liver is not uncommon in multiple myeloma (MM). However, a MM with hepatic mass is very unusual. We report a case of a 75-year-old male with hepatomegaly and a lesion occupying a voluminous space in the liver. A lambda light chain multiple myeloma was found in the check-up of this hepatic mass. We also provide(More)
Normal (N-) calf bone consists of lamellae regularly spaced and oriented parallel to the periosteum. The lamellae increase in thickness from the periosteum to the medullary cavity, by apposition of layers of cells and a calcifying matrix on either side of a hypercalcified primer. In the dermatosparactic (D-) bone, the hypercalcified primer is barely visible(More)
A simple and low-cost device is described which facilitates the calibration of intracellular DC recordings in amplitude and time. A current source, optically coupled to a conventional stimulator, injects a pulse of current, across a 1-omega resistor connecting the preparation to ground. Amplitude and duration of the current pulse are determined by adjusting(More)
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