Marc Moreau

Catherine Leclerc19
Isabelle Néant12
19Catherine Leclerc
12Isabelle Néant
6Sarah E Webb
6Andrew L Miller
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Calcium influx into lymphocytes is essential for activation, differentiation, and effector functions. While several channel- and receptor-types contribute to calcium influx, voltage-gated calcium channels (VGCC) mediate a well-characterized calcium influx pathway that is most exclusively identified in excitable cells. The role of L-type VGCCs, which belong(More)
  • Emmanuel Perisse, Valérie Raymond-Delpech, Isabelle Néant, Yukihisa Matsumoto, Catherine Leclerc, Marc Moreau +1 other
  • 2009
BACKGROUND Synaptic plasticity associated with an important wave of gene transcription and protein synthesis underlies long-term memory processes. Calcium (Ca2+) plays an important role in a variety of neuronal functions and indirect evidence suggests that it may be involved in synaptic plasticity and in the regulation of gene expression correlated to(More)
We take another look at the 2DR-tree. In particular, we revisit its node structure, validity rules and the insertion strategy. The 2DR-tree uses 2D nodes so that the relationships between all objects can be maintained. The existing structure has many advantages. However, two limitations include a high tree height and a low space utilization of its nodes. We(More)
Evidence indicates that a variety of different types of Ca2+ transients (i.e., standing gradients, pulses and propagating waves) may be occurring both simultaneously and sequentially during neural induction in vertebrate embryos. Transients have been observed in the dorsal marginal zone and in the presumptive neural ectoderm, suggesting that they may be(More)
In vertebrates, the formation of the nervous system starts at gastrulation with a process called neural induction. This process requires, at least in part, the inhibition of BMP signalling in the ectoderm by noggin, as well as FGF receptor activation and Ca2+ signalling. Our studies with Xenopus embryos suggest that an increase in intracellular Ca2+(More)
In Xenopus, experiments performed with isolated ectoderm suggest that neural determination is a 'by default' mechanism, which occurs when bone morphogenetic proteins (BMPs) are antagonized by extracellular antagonists, BMP being responsible for the determination of epidermis. However, Ca(2+) imaging of intact Xenopus embryos reveals patterns of Ca(2+)(More)
Development of the vertebrate embryonic nervous system is characterized by a cascade of signalling events. In Xenopus, the initial step in this cascade results from signals emanating from the dorsal mesoderm that divert the fate of the ectoderm from an epidermal to a neural lineage. These signals include extracellular antagonists of the bone morphogenetic(More)
In intact Xenopus embryos, an increase in intracellular Ca(2+) in the dorsal ectoderm is both necessary and sufficient to commit the ectoderm to a neural fate. However, the relationship between this Ca(2+) increase and the expression of early neural genes is as yet unknown. In intact embryos, studying the interaction between Ca(2+) signaling and gene(More)
We propose the mqr-tree, a two-dimensional spatial access method that improves upon the 2DR-tree. The 2DR-tree uses two-dimensional nodes so that the relationships between all objects are maintained. The existing structure of the 2DR-tree has many advantages. However, limitations include higher tree height, overcoverage and overlap than is necessary. The(More)