Marc Grégoire

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MUC1 glycoprotein is often found overexpressed and hypoglycosylated in tumor cells from numerous cancer types. Since its discovery MUC1 has been an attractive target for antitumor immunotherapy. Indeed, in vitro and in vivo experiments have shown T-cell-specific responses against MUC1 in an HLA-restricted and HLA-unrestricted manner, although some animal(More)
pro-inflammatory function but conserves IL-10 expression Heme oxygenase-1 expression inhibits dendritic cell maturation and (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: articles must include the digital object identifier(More)
Despite conventional medical and surgical treatments, malignant pleural mesothelioma (MPM) remains incurable. Onco-virotherapy (i.e., the use of replication-competent virus for cancer treatment) is currently explored in clinical trials. In this study, we investigated the antineoplastic potential of a new oncolytic viral agent, a live-attenuated measles(More)
Dendritic cell (DC) maturation is the process by which immature DC in the periphery differentiate into fully competent antigen-presenting cells that initiate the T cell response. However, DC respond to many distinct maturation stimuli, and different types of mature DC induce qualitatively different T cell responses. As DC maturation involves the coordinated(More)
Confronted with the inadequacy of traditional charts, we tested the contribution of Treemaps to the representation of medical data. Treemap charts allow description of large hierarchical collections of quantitative data, on a synthetic way. Treemaps were implemented using PHP5, and were tested in the field of DRG-mining and other medical informations. From(More)
INTRODUCTION This document presents some of the requirements and challenges associated with the visualisation for network situational awareness in computer network defence. It raises fundamental questions pertaining to the integration of information and its presentation to the user. Situational awareness is essential for decision makers to efficiently(More)
Lung and colorectal cancers are responsible for approximately 2 million deaths each year worldwide. Despite continual improvements, clinical management of these diseases remains challenging and development of novel therapies with increased efficacy is critical to address these major public health issues. Oncolytic viruses have shown promising results(More)
Antitumor virotherapy using oncolytic viruses (OV) is currently assessed in numerous clinical trials. 1 This therapeutic approach consists of the use of attenuated and/or genetically modified replication-competent virus to preferentially infect and kill tumor cells, with limited infection , if any, of healthy cells. Among the different oncolytic viruses,(More)
Malignant pleural mesothelioma (MPM) is a very aggressive form of cancer with a poor diagnosis and prognosis. The first line treatment for MPM is a combination of cisplatin and Pemetrexed, which displayed limited efficacy and severe side effects. The naturally occurring compound phenethyl isothiocyanate (PEITC) previously showed interesting anti-tumor(More)