Marc Grégoire

Jean-François Fonteneau6
Frédéric Tangy4
Carole Achard3
6Jean-François Fonteneau
4Frédéric Tangy
3Carole Achard
3Nicolas Boisgerault
2Mariana Mesel-Lemoine
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Dendritic cell (DC) maturation is the process by which immature DC in the periphery differentiate into fully competent antigen-presenting cells that initiate the T cell response. However, DC respond to many distinct maturation stimuli, and different types of mature DC induce qualitatively different T cell responses. As DC maturation involves the coordinated(More)
Confronted with the inadequacy of traditional charts, we tested the contribution of Treemaps to the representation of medical data. Treemap charts allow description of large hierarchical collections of quantitative data, on a synthetic way. Treemaps were implemented using PHP5, and were tested in the field of DRG-mining and other medical informations. From(More)
  • Nicolas Boisgerault, Jean-Baptiste Guillerme, Daniel Pouliquen, Mariana Mesel-Lemoine, Carole Achard, Chantal Combredet +3 others
  • 2013
Lung and colorectal cancers are responsible for approximately 2 million deaths each year worldwide. Despite continual improvements, clinical management of these diseases remains challenging and development of novel therapies with increased efficacy is critical to address these major public health issues. Oncolytic viruses have shown promising results(More)
  • Jean-François Fonteneau, Jean-Baptiste Guillerme, Frédéric Tangy, Marc Grégoire
  • 2013
Antitumor virotherapy using oncolytic viruses (OV) is currently assessed in numerous clinical trials. 1 This therapeutic approach consists of the use of attenuated and/or genetically modified replication-competent virus to preferentially infect and kill tumor cells, with limited infection , if any, of healthy cells. Among the different oncolytic viruses,(More)
  • Carole Achard, Nicolas Boisgerault, Tiphaine Delaunay, David Roulois, Steven Nedellec, Pierre-Joseph Royer +8 others
  • 2015
Attenuated measles virus (MV) is currently being evaluated as an oncolytic virus in clinical trials and could represent a new therapeutic approach for malignant pleural mesothelioma (MPM). Herein, we screened the sensitivity to MV infection and replication of twenty-two human MPM cell lines and some healthy primary cells. We show that MV replicates in(More)
Cancer virotherapy is an attractive alternative to conventional treatments because it offers a wide range of antitumor effects due to 1) the diversity of the oncolytic viruses that are now available and 2) their multifaceted activities against both tumor cells and tumor vessels, in addition to their ability to induce antitumor immune responses. In this(More)
MUC1 glycoprotein is often found overexpressed and hypoglycosylated in tumor cells from numerous cancer types. Since its discovery MUC1 has been an attractive target for antitumor immunotherapy. Indeed, in vitro and in vivo experiments have shown T-cell-specific responses against MUC1 in an HLA-restricted and HLA-unrestricted manner, although some animal(More)
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