Marc G Jacobson

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PURPOSE INGN 201 (Ad-p53) is a replication-defective adenoviral vector that encodes a wild-type p53 gene driven by the cytomegalovirus promoter. INGN 201 has been shown to have antitumoral activity against human prostate cancer cell lines. This study was undertaken to determine the safety of INGN 201 in patients with locally advanced prostate cancer, to(More)
PURPOSE The primary objective of this phase I trial was to define the maximum-tolerated dose of continuous-infusion doxorubicin administered with standard preoperative radiation for patients with localized, potentially resectable soft tissue sarcomas of the extremities or body wall. PATIENTS AND METHODS Twenty-seven patients with radiographically(More)
Sixteen patients with the occlusion of the internal carotid artery (ICA) underwent extra-intracranial bypass surgery. All patients had stroke in evolution or completed stroke with mild or moderate (n = 9) or severe (n = 7) neurological deficits. In each case, the clinical course, magnetic resonance imaging (MRI), computed tomography (CT) and angiographic(More)
Of the 47 patients with focal cerebral ischemia (FCI), 26 patients had completed stroke, 5 suffered from severe head injury, and 16 patients had anterior circulation aneurysms. Twenty-one stroke patients underwent bypass surgery and all traumatic patients underwent cerebral revascularization by omental graft. Aneurysm patients were surgically treated by(More)
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