Marc Delmotte

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Heterodimerization of retinoic acid receptors (RARs) with 9-cis-retinoic receptors (RXRs) is a prerequisite for binding of RXR.RAR dimers to DNA and for retinoic acid-induced gene regulation. Whether retinoids control RXR/RAR solution interaction remains a debated question, and we have used in vitro and in vivo protein interaction assays to investigate the(More)
Transcriptional activation by retinoids is mediated through two families of nuclear receptors, all-trans-retinoic acid (RARs) and 9-cis retinoic acid receptors (RXRs). Conformationally restricted retinoids are used to achieve selective activation of RAR isotype alpha, beta or gamma, which reduces side effects in therapeutical applications. Synthetic(More)
[1] On the basis of long simulations performed with a three-dimensional climate model, we propose an interhemispheric climate lag mechanism, involving the long-term memory of deepwater masses. Warm anomalies, formed in the North Atlantic when warm conditions prevail at surface, are transported by the deep ocean circulation towards the Southern Ocean. There,(More)
The last deglaciation was marked by large, hemispheric, millennial-scale climate variations: the Bølling-Allerød and Younger Dryas periods in the north, and the Antarctic Cold Reversal in the south. A chronology from the high-accumulation Law Dome East Antarctic ice core constrains the relative timing of these two events and provides strong evidence that(More)
Retinoic acid (RA) regulation of cellular proliferation and differentiation is mediated, at least in part, through two related nuclear receptors, RAR and RXR. RA-induced modulation of gene expression leads generally to cellular differentiation, whereas stimulation of the protein kinase C (PKC) signaling pathway is associated with cellular proliferation.(More)
We have developed a tunable diode laser spectrometer, called SIMCO (spectrometer for isotopic measurements of CO(2)), for determining the concentrations of (12)CO(2) and (13)CO(2) in atmospheric air, from which the total concentration of CO(2) and the isotopic composition (expressed in delta units) delta(13)CO(2) are calculated. The two concentrations are(More)
BACKGROUND Aging and obesity induce complex transcriptomic changes in the liver, promoting the development of insulin resistance and type 2 diabetes. In spite of an increasing amount of studies on the role of aging and nutrient excess in metabolic disorders, the specific molecular events leading to insulin resistance are still poorly understood. METHODS(More)
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