Marc C. Wood

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Visual search and identification of analyzable metaphase chromosomes using optical microscopes is a very tedious and time-consuming task that is routinely performed in genetic laboratories to detect and diagnose cancers and genetic diseases. The purpose of this study is to develop and test a computerized scheme that can automatically identify chromosomes in(More)
We developed and tested a new automated chromosome karyotyping scheme using a two-layer classification platform. Our hypothesis is that by selecting most effective feature sets and adaptively optimizing classifiers for the different groups of chromosomes with similar image characteristics, we can reduce the complexity of automated karyotyping scheme and(More)
Multiphoton resonance ionization (MPRI) has been combined with ion-beam-induced desorption to examine a set of thermally labile biological molecules present on surfaces. Specifically, we have examined films of adenine and beta-estradiol, molecules with a rigid skeletal backbone. In both of these cases, molecular ions could be produced efficiently without(More)
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been utilized to detect femtomole and attomole quantities of organic species from within silicon nanovials. By using high-density arrays (10,000 nanovials/cm2) it is possible to chemically characterize diverse sample sets within a single chemical image. Molecular sensitivities, for the compounds(More)
The behavior of smoke injected into the atmosphere by massive fires that might follow a nuclear war was simulated. Studies with a three-dimensional global atmospheric circulation model showed that heating of the smoke by sunlight would be important and might produce several effects that would decrease the efficiency with which precipitation removes smoke(More)
In this study, ion-beam-induced desorption with multiphoton resonance ionization detection of desorbed neutral molecules is used to characterize frozen aqueous solutions. This type of matrix is of particular importance since it serves as a model for biological matrices. The time-of-flight mass spectrum, obtained in this way for a millimolar tryptophan/H2O(More)
We investigate the use of a liquid metal ion gun (LMIG) combined with multiphoton resonance ionization of sputtered atoms and/or molecules to acquire mass-selected images with submicrometer spatial resolution. Images from several model systems are presented including those of an In grid, and of patterned surfaces of benzo[a]pyrene and tryptophan thin films.(More)
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