Marc Braunstein

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Angiogenesis governs the progression of multiple myeloma (MM). Circulating endothelial cells (CECs) contribute to angiogenesis and comprise mature ECs and endothelial progenitor cells (EPCs). The present study sought to characterize CECs and their relation to disease activity and therapeutic response in 31 consecutive patients with MM. CECs, identified as(More)
Tetrathiomolybdate (choline salt; ATN-224), a specific, high-affinity copper binder, is currently being evaluated in several phase II cancer trials. ATN-224 inhibits CuZn superoxide dismutase 1 (SOD1) leading to antiangiogenic and antitumour effects. The pharmacodynamics of tetrathiomolybdate has been followed by tracking ceruloplasmin (Cp), a biomarker for(More)
Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable, primarily due to the treatment-refractory/resistant nature of the disease. A rational approach to this compelling challenge is to develop new drugs that act synergistically with existing effective agents. This approach will reduce drug concentrations, avoid(More)
In multiple myeloma (MM), increased neoangiogenesis contributes to tumor growth and disease progression. Increased levels of endothelial progenitor cells (EPCs) contribute to neoangiogenesis in MM, and, importantly, covary with disease activity and response to treatment. In order to understand the mechanisms responsible for increased EPC levels and(More)
BACKGROUND Climate factors and pollen counts may play a role in hay fever. OBJECTIVE We sought to determine the impact of specific climate factors and pollen counts on the US prevalence of hay fever and statewide variation in prevalence. METHODS We used a merged analysis of the 2007 National Survey of Children's Health from a representative sample of(More)
A 401k plan is a defined contribution pension plan provided by employers to employees in the USA. Each plan is established by an employer and allows employees to set aside pre-tax dollars for investment into a basket of securities, typically mutual funds and company stock. One common investment option made available to policy holders are stable value funds(More)
(4217 articles) Neoplasia • (2497 articles) Hemostasis, Thrombosis, and Vascular Biology • Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at:(More)
For investigations of human B-cell receptor (BCR) repertoires, we have developed a protocol for large-scale surveys of human antibody heavy chain (VH) rearrangements. Here we study IgA repertoires, as more IgA antibodies are synthesized in the human body on a daily level than all other isotypes combined. In fact, IgA is secreted at all mucosal surfaces, and(More)
17555 Background: The incidence of multiple myeloma (MM) is high in African Americans (AA), who are underrepresented in clinical trials. This Phase II trial assessed thalidomide (100 mg/day), dexamethasone (10-40 mg for 4 days/week x3 for 6 months, then 4 days/month), and zoledronate (4 mg/4 weeks) (TDZ) in newly diagnosed AA patients with MM. TDZ was(More)
The expanding armamentarium of novel agents used in combination to treat multiple myeloma (MM) can induce clinical responses in most newly diagnosed patients, with encouraging outcomes observed in the relapsed/refractory setting. Highly sensitive techniques to detect minimal residual disease (MRD) are increasingly being employed to gauge the depth of(More)