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It is suggested that the propagation of the action potential is accompanied by an axoplasmic pressure pulse propagating in the axoplasm along the axon length. The pressure pulse stretch-modulates voltage-gated Na + (Nav) channels embedded in the axon membrane, causing their accelerated activation and inactivation and increasing peak channel conductance. As(More)
This paper proposes a neuronal circuitry layout and synaptic plasticity principles that allow the (pyramidal) neuron to act as a "combinatorial switch". Namely, the neuron learns to be more prone to generate spikes given those combinations of firing input neurons for which a previous spiking of the neuron had been followed by a positive global reward(More)
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