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Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates.

• Francesco Benedetti, Barbara Barbini, +4 authors Enrico Smeraldi
• The Journal of clinical psychiatry
• 2005

BACKGROUND Drug resistance remains a persistent source of morbidity and mortality for patients with bipolar depression. A growing number of clinical studies support the usefulness of… (More)

Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.

• Francesco Benedetti, Sara Dallaspezia, +5 authors Enrico Smeraldi
• American journal of medical genetics. Part B…
• 2007

Depressive insomnia and diurnal fluctuations of mood and activity are core clinical features of mood disorders. Here we studied the effect of CLOCK 3111 T/C SNP (rs1801260) on the actimetric recorded… (More)

Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism.

• Francesco Benedetti, Barbara Barbini, +9 authors Cristina Colombo
• Journal of affective disorders
• 2010

Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity. It is a current area… (More)

Dopaminergic augmentation of sleep deprivation effects in bipolar depression

• Francesco Benedetti, Euridice Campori, Barbara Barbini, Mara Cigala Fulgosi, Cristina Colombo
• Psychiatry Research
• 2001

Total sleep deprivation (TSD) has been used in association with lithium salts and with serotonergic and noradrenergic antidepressants, leading to sustained improvements in patients affected by major… (More)

Seasonality and Sleep: A Clinical Study on Euthymic Mood Disorder Patients

• Chiara Brambilla, Chiara Gavinelli, +4 authors Enrico Smeraldi
• Depression research and treatment
• 2012

Background. Research on mood disorders has progressively focused on the study of seasons and on the mood in association with them during depressive or manic episodes yet few studies have focused on… (More)

Optimized light therapy for non-seasonal major depressive disorder: effects of timing and season.

• Sara Dallaspezia, Francesco Benedetti, +4 authors Enrico Smeraldi
• Journal of affective disorders
• 2012

BACKGROUND Light Therapy (LT) when combined with standard antidepressant treatment for unipolar depression hastens recovery. We studied the influence of LT timing on the antidepressant efficacy of LT… (More)

Serotonin 5-HT<ce:inf loc=post>2A</ce:inf> receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression

• Francesco Benedetti, Barbara Barbini, Alessandro Bernasconi, Mara Cigala Fulgosi, Enrico Smeraldi
• Progress in Neuro-Psychopharmacology and…
• 2008

5-HT2A receptor density in prefrontal cortex was associated with depression and suicide. 5-HT2A receptor gene polymorphism rs6313 was associated with 5-HT2A receptor binding potential, with the… (More)

P.1.121 Rapid assessment of cognitive distorsions in major depression

• Mara Cigala Fulgosi, Francesco Benedetti, Marcello Florita, Christian Colombo, Enrico Smeraldi
• European Neuropsychopharmacology
• 2003

Sleep phase advance and lithium to sustain the antidepressant effect of total sleep deprivation in bipolar depression: new findings supporting the internal coincidence model?

• Francesco Benedetti, Barbara Barbini, Euridice Campori, Mara Cigala Fulgosi, Adriana Pontiggia, Cristina Colombo
• Journal of psychiatric research
• 2001

Recent European studies suggested that sleep phase advance (SPA) could sustain the effects of total sleep deprivation (TSD) both with or without a combined antidepressant drug treatment. Previous… (More)

P.2.a.019 An actigraphic registration of depressed patients treated with chronotherapeutics

• Adriana Pontiggia, Fabrizio Benedetti, Barbara Barbini, Mara Cigala Fulgosi, Enrico Smeraldi
• European Neuropsychopharmacology
• 2006

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