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Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene
MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development isExpand
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Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells.
There is growing evidence about the role of mesenchymal stem cells (MSCs) as cancer stem cells in many sarcomas. Nevertheless, little is still known about the cellular and molecular mechanismsExpand
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Nuclear factor-κ B inducing kinase is required for graft-versus-host disease
Background Donor T lymphocytes are directly responsible for graft-versus-host disease. Molecules important in T-cell function may, therefore, be appropriate targets for graft-versus-host diseaseExpand
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Bone marrow mesenchymal stem cells from infants with MLL-AF 4 + acute leukemia harbor and express the MLL-AF 4 fusion gene
The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 13 3131-3141 www.jem.org/cgi/doi/10.1084/jem.20091050 3131 Pediatric leukemias possess unique biological features. They areExpand
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