Marína Sidorová

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The interaction of 11 overlapping synthetic peptides corresponding to N-terminal segment of HIV transmembrane glycoprotein gp41 (fusion domain) with artificial lipid membranes has been studied. For this purpose the increase of a bilayer lipid membrane (BLM) conductivity and the changes in ESR spectra of spin-labelled liposomes were registrated. Peptide(More)
Tandem repeats belong to a class of genomic repetitive elements that form arrays of head-to-tail monomers. Due to technical difficulties in sequencing and assembly of large tandem repeat arrays, it remains largely unknown by which mechanisms tandem-repeat-containing regions aid in maintenance of ordered radial genome organization during interphase. Here we(More)
The mechanism of antiviral activity of the CD4-derived peptide 75-99 was compared with that of sulfated polysaccharides. A set of peptides representing all the high positive charge density regions of gp120 and gp41 was used to determine whether electrostatic interactions occur between these negatively charged agents and positively charged HIV envelope(More)
Energetic dependency on the oil reserve-resources of crude oil in the world Crude oil belongs to the most important energy resources nowadays., However its reserves are the smallest in comparison with other energy resources as coal, gas or uranium. The world oil consumption continuously increases and within 20-year period there could be about one third. So,(More)
Low-potencial Earth thermalEnergy Utilization in Heat Pump Systems The underground in the first approx. 100 m is well suited for supply and storage of thermal energy. The climatic temperature change over the seasons is reduced to a steady temperature at 10-20 m. With further depth, the temperatures increase according to the geothermal gradient (average 3 °C(More)
The paper is devoted to the development of a system of program-oriented postgraduate education of radiologists based methodologically on acquiring professional knowledge and skills. Educational goals were adapted for each subject area. Matrix analysis and plotting of a logical structure graph were used for a choice of the final goals of education. The(More)
A pedagogical experiment was used to study the effectiveness of a system of program-purpose teaching in postgraduate training of radiologists differing from the classic methods aimed at end goals. A total of 150 pedagogical tests on 240 students using parallel and cross methods were performed. The use of the system of program-purpose teaching intensifies(More)
BACKGROUND microRNAs have recently been identified as powerful biomarkers of human disease. Reliable polymerase chain reaction (PCR)-based quantification of nucleic acids in clinical samples contaminated with polymerase inhibitor heparin requires deheparinization. However, the effects of deheparinization procedure on quantification of nucleic acids remain(More)