María del Carmen Ordóñez

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The distribution of PrP(BSE) in the brain of nine confirmed BSE field cases was analyzed using immunohistochemistry and compared to the levels of PrP(BSE) determined by two rapid tests (Prionics-Check WESTERN and Prionics-Check LIA). Each brain was dissected into 16 areas: spinal cord, medulla oblongata, pons, mesencephalon, thalamus, hippocampus,(More)
INTRODUCTION We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). METHODS The G1m genotypes were analyzed in(More)
INTRODUCTION Microthrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN. METHODS Kidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with(More)
INTRODUCTION In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). The authors of that study reported that the four genetic(More)
Fernández L, Díez C, Ordóñez JM, et al. Reproductive performance in primiparous sows after postweaning treatment with a progestagen. Summary The purpose of this study was to determine whether administration of altrenogest (Regumate; Roussel-Uclaf, París, France) to primiparous sows would improve estrus synchronization rate and reproductive efficiency of the(More)
  • S Siso, Puig B, Varea R Vidal, Acin C, Prinz M, E Vidal +36 others
  • 2011
Abnormal synaptic protein expression and cell death in murine scrapie. Comparative study of the PrPBSE distribution in brains from BSE field cases using rapid tests. diagnosis of preclinical and clinical scrapie in sheep by the detection of disease‐associated PrP in their rectal mucosa. phenotype of experimental ovine BSE is maintained after blood(More)
In humans, familial prion diseases are linked to mutations in the PRNP gene. We have sequenced part of this gene in a large sample of common chimpanzee, Pan troglodytes (n=130 chromosomes). No variation in codons 129 and 219 has been observed: all chimpanzees were homozygous for the Met allele, which in humans increases susceptibility to Creutzfeldt-Jakob(More)
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