María Teresa Fernández

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BACKGROUND Cord-blood banks have increased the use of cord-blood transplantation in patients with hematologic disorders. We have established a registry containing information on the outcome of cord-blood transplantation. METHODS We sent questionnaires to 45 transplantation centers for information on patients receiving cord-blood transplants from 1988 to(More)
Impact factor is a quasi-qualitative indicator, which provides a measurement of the prestige and international visibility of journals. Although the use of impact factor-based indicators for science policy purposes has increased over the last two decades, several limitations have been pointed out and should be borne in mind. The use of impact factor should(More)
The effect of interferon-beta in multiple sclerosis is modest and many patients do not respond to treatment. To date, no single biomarker reliably correlates with responsiveness to interferon-beta in multiple sclerosis. In the present study, genome-wide expression profiling was performed in peripheral blood mononuclear cells from 47 multiple sclerosis(More)
Productivity and impact of the Spanish Council for Scientific Research scientists in Natural Resources and Chemistry by gender and professional category are analysed. Scientific publications were downloaded from the Science Citation Index, years 1994-1999. A total of 260 Natural Resources scientists (24% of females) and 219 Chemistry ones (38% of females)(More)
Treatment of fetal rat hepatocytes with transforming growth factor beta (TGF-beta) is followed by apoptotic cell death. Analysis of radical oxygen species (ROS) content and mitochondrial transmembrane potential (Deltapsim), using specific fluorescent probes in FACScan and confocal microscopy, showed that TGF-beta mediates ROS production that precedes the(More)
The tumor promoter okadaic acid (OKA), is a marine toxin of algal origin, identified as a potent inhibitor of protein phosphatases 1 and 2A, and possibly enhancing calcium influx through voltage dependent calcium channels (VSSC). We now report that OKA at concentrations as low as 0.5 nM produced neurotoxicity, characterized first by the desintegration of(More)
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, quality control and development of antivenoms in Latin America. The ability of seven polyspecific antivenoms, produced in Argentina,(More)
As part of a project on lentil molecular genetics, the sequence of the 18S-25S ribosomal RNA gene intergenic spacer (IGS) of Lens culinaris Medik. was determined. DNA was cloned after polymerase chain reaction (PCR) amplification. The spacer of 2939 bp was composed of nonrepetitive sequences and four tandem arrays of repeated sequences, named A to D. C and(More)
The effect of three commercial proteases (pronase E from Streptomyces griseus, aspartyl proteinase from Aspergillus oryzae and papain) on protein breakdown and the sensory characteristics of dry fermented sausages was investigated. Water soluble, non-protein, 5% phosphotungstic acid soluble, 5% sulphosalicylic acid soluble and total volatile basic nitrogen(More)
Samples of honeybees (Apis mellifera, n = 92) from 14 beehive monitoring stations located in 3 townships in the province of Bologna were analyzed from April to October 2000. The concentration of 32 organophosphorus pesticides and 5 carbamates was determined through liquid-liquid extraction followed by gas chromatography with a nitrogen-phosphorus detector(More)