María Ruiz-Tovar

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INTRODUCTION Sporadic Creutzfeldt-Jakob disease (sCJD) might be transmitted by surgery. The purpose of this study was to investigate potential susceptibility to sCJD from surgery at juvenile age and in early adulthood. METHODS From Danish and Swedish national registries we identified 167 definite and probable sCJD cases with onset from 1987 through 2003,(More)
BACKGROUND During the last two decades, protein aggregation at all organismal levels, from viruses to humans, has emerged from a neglected area of protein science to become a central issue in biology and biomedicine. This article constitutes a risk-based review aimed at supporting an etiologic scenario of selected, sporadic, protein-associated, i.e.,(More)
BACKGROUND Studies have shown a slight excess risk in Guillain-Barré syndrome (GBS) incidence associated with A(H1N1)pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009-2010. We aimed to assess the incidence of GBS as a potential adverse effect of A(H1N1)pdm09 vaccination. METHODS A neurologist-led network, active at(More)
INTRODUCTION Increasing incidences or mortality rates from brain malignant tumors have been reported in several countries. OBJECTIVE This is a review of the studies published by the Cancer Epidemiology Unit of Carlos III Health Institute on incidence and mortality from these tumors in adults and children in Spain. RESULTS During the period 1952-1986(More)
We analyzed time trends in mortality from malignant tumors of the nervous system (MTNS) in the adult Spanish population during the period 1952-1986, using Poisson regression analysis of age at death, year of birth and year of death. During such period, mortality rose especially in the elderly as well as among young and middle-aged men. We found two modest(More)
Spain has one of the highest incidences of bacterial resistance to antimicrobials, possibly linked to drug consumption patterns. Using Ministry of Health and Consumer Affairs records, data were obtained on non-hospital sales of antibiotics for the period 1987-1997, and equivalents calculated in weight of active drug ingredient and defined daily doses per(More)
In 2009, a pathologist with sporadic Creutzfeldt-Jakob Disease (sCJD) was reported to the Spanish registry. This case prompted a request for information on health-related occupation in sCJD cases from countries participating in the European Creutzfeldt Jakob Disease Surveillance network (EuroCJD). Responses from registries in 21 countries revealed that of(More)
Using log-linear Poisson modelling, trends in childhood cancer mortality among the population under 20 years of age in Spain are described over the 35-year period from 1956 to 1990. Overall cancer mortality and seven specific sites were considered: all leukaemias, Hodgkin's disease, non-Hodgkin's lymphomas, malignant brain tumours, kidney cancer, malignant(More)
BACKGROUND The purpose of this study was to identify incidence and survival patterns in conformational neurodegenerative disorders (CNDDs). METHODS We identified 2563 reports on the incidence of eight conditions representing sporadic, acquired and genetic, protein-associated, i.e., conformational, NDD groups and age-related macular degeneration (AMD). We(More)
BACKGROUND Sporadic Creutzfeldt-Jakob disease (sCJD) is potentially transmissible to humans. OBJECTIVE This study aimed to summarise and rate the quality of the evidence of the association between surgery and sCJD. DESIGN AND METHODS Firstly, we conducted systematic reviews and meta-analyses of case-control studies with major surgical procedures as(More)