María Rosario Blasco

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OBJECTIVE Patients with early multiple sclerosis (MS) have stereotyped attack severity and recovery. We sought to determine if polymorphisms in MS susceptibility genes are associated with these attack features or with the risk of a second attack. METHODS 503 white subjects evaluated within a year of MS onset were included in the study. The severity of and(More)
Progress in understanding the pathophysiology of MS has shown that irreversible damage to the central nervous system may occur early in the disease course. Evidence from clinical trials suggests that part of this damage might be prevented by the early use of disease modifying drugs; this therefore increases the importance of an early MS diagnosis. All(More)
Current evidence suggests that multiple sclerosis (MS) results from an autoimmune response mediated by T lymphocytes, which would be activated in the peripheral blood and migrate into the central nervous system. NFkappaB and AP-1 are two main transcription factors involved in T-cell activation. To investigate possible alterations in the activity of these(More)
Aminoguanidine therapy delayed the onset of actively induced EAE in Lewis rats, but recovery was impaired in most animals. In the central nervous system this was correlated with persistent inflammation and production of proinflammatory cytokines. In the periphery of aminoguanidine-treated animals, T lymphocytes showed increased proliferation against myelin(More)
OBJECTIVE The anatomic location of subsequent relapses in early multiple sclerosis (MS) appears to be predicted by the first attack location. We sought to determine if genetic polymorphisms associated with MS susceptibility are associated with attack location. METHODS 17 genome-wide association study-identified MS susceptibility polymorphisms were(More)
Alemtuzumab is a humanized monoclonal antibody used to treat active relapsing-remitting multiple sclerosis (RRMS) defined by clinical or imaging features. It is directed against glycoprotein CD52, and causes lysis and rapid depletion of circulating T and B lymphocytes which are thought to be critical mediators of multiple sclerosis (MS) [1, 2]. Cytokine(More)
INTRODUCTION Spontaneous intracranial hypotension (SIH) is an uncommon condition. The main symptom is headache which appears on standing and is relieved by lying down. Diagnosis is confirmed if a CSF pressure of less than 6 cm of water is found in the absence of other causes of intracranial hypotension. OBJECTIVE To describe the cranial MR and CT findings(More)