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Protein phosphatase 2A (PP2A) is a tumor suppressor that regulates many signaling pathways crucial for cell transformation. In fact, decreased activity of PP2A has been reported as a recurrent alteration in many types of cancer. Here, we show that PP2A is frequently inactivated in patients with colorectal cancer, indicating that PP2A represents a potential(More)
This manual is designed to help health care staff learn how to accurately complete the RVCT. Included are the instructions for how to complete each item on the RVCT and exercises that will help you apply the instructions to lifelike situations. CDC would also like to thank all of the state and local health departments whose staff participated in the field(More)
Traditionally, web standards in general and Cascading Style Sheets (CSS) in particular take a long time from when they are defined by the W3C until they are implemented by browser vendors. This has been a limitation not only for authors, who had to wait even years before they were able to use certain CSS properties in their web pages, but also for the(More)
This manual includes the instructions for how to complete each item on the RVCT. It can be used as a reference guide when completing the RVCT. The exercises from the RVCT Self-Study Modules that are used to practice completing the RVCT are not included in this manual. CDC would also like to thank all of the state and local health departments whose staff(More)
Choice design building based on D-error minimization can be accomplished either by using predefined β values or by assuming probabilistic distributions for them. Several mathematical techniques have been used for both approaches in the past, resulting in algorithms that obtain efficient designs, which guarantee the high quality of the information that will(More)
The limited clinical success of anti-HGF/MET drugs can be attributed to the lack of predictive biomarkers that adequately select patients for treatment. We demonstrate here that quantitative digital imaging of formalin fixed paraffin embedded tissues stained by immunohistochemistry can be used to measure signals from weakly staining antibodies and provides(More)
and many other staff at Jobs for Youth/Chicago, all of whom provided essential assistance in the assembly of data for this research. The views expressed in this paper are those of the authors and do not necessarily reflect those who provided funding or assistance to this project. IRP publications(discussion papers, special reports, and the newsletter Focus)(More)
The Lab is actively engaged in design and development of next-generation computing systems and applications that aggregate by dynamically leasing services of distributed resources depending on their availability, capability, performance, cost, and users' QoS requirements. The Cloudbus project, an initiative that started in 2008 by the CLOUDS lab at the(More)
This paper analyzes possible arbitrage opportunities in credit derivatives markets using self-…nancing strategies combining Credit Default Swaps and Asset Swaps Packages. We present a new statistical arbitrage test based on the subsampling methodology which has lower Type I error than existing alternatives. Using four di¤erent databases covering the period(More)