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  • Beatriz Bonaga Serrano, María José García Sánchez, María José Otero, Dolores Santos Buelga, Juan José Rey Serrano, Alfonso Domínguez-Gil
  • Medicine
  • Journal of clinical pharmacy and therapeutics
  • 1999 (First Publication: 1 February 1999)
  • OBJECTIVE A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL). METHODS AExpand
  • Salvador Enrique Cabrera Figueroa, María del Mar Fernández de Gatta, +4 authors María José García Sánchez
  • Medicine
  • Therapeutic drug monitoring
  • 2010 (First Publication: 1 October 2010)
  • The aim of this study was to show the benefits of combining therapeutic drug monitoring (TDM) and pharmacogenetic analyses to optimize efavirenz (EFV) therapy. Patients were selected to minimizeExpand
    The aim of the study was to characterize, from the relationship between total and free serum levels of valproic acid obtained over a broad dosage range (10-50 mg/kg), the parameters defining theExpand
    The aim of the authors' study was to investigate the factors affecting carbamazepine (CBZ) clearance (CL) in children with epilepsy. The factors evaluated were total body weight (TBW), age, dose,Expand
  • Montserrat Pérez Encinas, D Santos Buelga, A C Alonso González, María José García Sánchez, Alfonso Domínguez-Gil Hurlé
  • Medicine
  • Journal of clinical pharmacy and therapeutics
  • 1992 (First Publication: 1 February 1992)
  • A combination of anti-epileptic drugs gives rise to interactions that modify their disposition kinetics. To discover the clinical relevance of such interactions it is necessary to establish theirExpand
    A rapid and simple UHPLC-fluorescence detection method for the quantification of doxorubicin and its main metabolite, doxorubicinol, in human plasma has been developed. The method was also validatedExpand
  • M R Fernández de Gatta, A C Alonso González, María José García Sánchez, A. Domínguez-Gil Hurlé, J. Santos Borbujo, L. Monzon Corral
  • Medicine
  • Therapeutic drug monitoring
  • 1986 (First Publication: 1 December 1986)
  • Summary: The influence of sodium valproate on serum levels of phenobarbital during combination treatment was studied in 29 children and 50 adults with epilepsy. Steady-state drug levels in serum wereExpand