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The detection of microaneurysms in digital color fundus photographs is a critical first step in automated screening for diabetic retinopathy (DR), a common complication of diabetes. To accomplish this detection numerous methods have been published in the past but none of these was compared with each other on the same data. In this work we present the(More)
In this study we have investigated the electroencephalogram (EEG) background activity in patients with Alzheimer's disease (AD) using non-linear analysis methods. We calculated the Lempel-Ziv (LZ) complexity - applying two different sequence conversion methods - and the central tendency measure (CTM) of the EEG in 11 AD patients and 11 age-matched control(More)
Diabetic Retinopathy is one of the leading causes of blindness in developed countries. Hard exudates have been found to be one of the most prevalent earliest clinical signs of retinopathy. Thus, automatic detection of hard exudates from retinal images is clinically significant. In this study, an automatic method to detect hard exudates is proposed. The(More)
Diabetic retinopathy (DR) is an important cause of visual impairment in developed countries. Automatic recognition of DR lesions in fundus images can contribute to the diagnosis of the disease. The aim of this study is to automatically detect one of these lesions, hard exudates (EXs), in order to help ophthalmologists in the diagnosis and follow-up of the(More)
In this study, we explored the ability of several spectral based measures to summarize the information of the power spectral density (PSD) function from spontaneous magnetoencephalographic (MEG) activity in Alzheimer's disease (AD). The MEGs of 20 AD patients and 21 elderly controls were recorded with eyes closed at rest during 5 min from 148 channels. Five(More)
BACKGROUND Food allergy may be life-threatening, and patients affected need to receive accurate diagnoses and treatment. Hazelnut has often been implicated as responsible for allergic reactions, and trace quantities can induce systemic reactions. OBJECTIVE The aim of this study was to evaluate the efficacy and tolerance of sublingual immunotherapy with a(More)
Diabetic retinopathy (DR) is a disease with an increasing prevalence and the main cause of blindness among working-age population. The risk of severe vision loss can be significantly reduced by timely diagnosis and treatment. Systematic screening for DR has been identified as a cost-effective way to save health services resources. Automatic retinal image(More)
Alzheimer's disease (AD) is the most common cause of dementia. Over the last few years, a considerable effort has been devoted to exploring new biomarkers. Nevertheless, a better understanding of brain dynamics is still required to optimize therapeutic strategies. In this regard, the characterization of mild cognitive impairment (MCI) is crucial, due to the(More)
BACKGROUND Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the administration of Insulin-Like Growth Factor-I (IGF-I). The aims of this study were to explore the evolution of these alterations and(More)
The aim of this study was to analyze the magnetoencephalography (MEG) background activity in Attention-Deficit/Hyperactivity Disorder (ADHD) using a regularity measure: sample entropy (SampEn). Five minutes of recording were acquired with a 148-channel whole-head magnetometer in 14 ADHD patients and 14 control subjects. Our results showed that ADHD(More)