María Elena González

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Increased levels of EZH2, a critical regulator of cellular memory, are associated with negative estrogen receptor (ER) expression and disease progression in breast cancer. High levels of EZH2 signal the presence of metastasis and poor outcome in breast cancer patients. To test the hypothesis that deregulation of EZH2 contributes to ER negative breast cancer(More)
Checkpoint with FHA and Ring Finger (CHFR) is hypothesized to mediate a delay in cell cycle progression early in mitosis in response to microtubule stress, independent of the spindle assembly checkpoint. As a potential regulator of cell cycle progression, CHFR naturally becomes an interesting target for understanding cancer cells. In recent years, there has(More)
Increasing evidence supports that the epithelial to mesenchymal transition (EMT) in breast cancer cells generates tumor initiating cells (TICs) but the contribution of the tumor microenvironment to these programs needs further elucidation. CCN6 (WISP3) is a secreted matrix-associated protein (36.9 kDa) of the CCN family (named after CTGF, Cyr61 and Nov)(More)
Advanced food processing methods that accomplish inactivation of microorganisms but minimize adverse thermal exposure are of great interest to the food industry. High pressure (HP) and pulsed electric field (PEF) processing are commercially applied to produce high quality fruit and vegetable products in the United States, Europe, and Japan. Both microbial(More)
The present work focuses on the physiopathology of Parkinson's disease (PD), analyzing the alterations in neuro-transmitter profile of the basal ganglia triggered by the degeneration of cells from the substantia nigra compacta (SNpc). For this purpose, the neurochemical, morphological and molecular changes of the pedunculopontine nucleus (PPN) of rats upon(More)
Glutamatergic antagonists were administered in rats, as part of the current pharmacological therapies for neuroprotection of patients with Parkinson disease, due to glutamatergic hyperactivity and the deleterious effects of this condition. The effect of the systemic administration of MK-801, an antagonist of N-methyl-D-aspartate (NMDA) receptors, was(More)
Efecto neuroprotector de la administración sistémica de MK-801 en el núcleo pedunculopontino de ratas hemiparkinsonizadas ABSTRACT Neuroprotective effects of MK-801 systemic administration on the pedunculopontine nucleus of hemiparkinsonian rats. Some glutamatergic antagonists have been administered as part of the pharmacologic strategies direct towards at(More)
Increase in the extracellular concentration of amino acid neurotransmitters and cell death on the pedunculopontine nucleus of hemiparkinsonian rats upon intracerebral injection of 6-hydroxy dopamine ABSTRACT Although the dysfunctions of the pedunculopontine nucleus (PPN) have been linked in the last decade to the physiopathology of Parkinson's disease (PD),(More)