María Del Carmen De Andrés

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This study investigated the distribution of thyrotropin-releasing hormone-immunoreactive (TRHir) neurons and fibers in the brain and retina of lampreys. Our results in the brains of large larvae and upstream-migrating adults of the sea lamprey showed the presence of TRHir neurons mainly in the preoptic region and the hypothalamus. A few TRHir neurons were(More)
OBJECTIVE To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. METHODS Expression levels were determined using quantitative reverse transcription-polymerase chain reaction, and the percentage of DNA(More)
INTRODUCTION The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase (iNOS) induced by inflammatory cytokines. NO donors represent a powerful tool for studying the role of NO in the cartilage in vitro. There is no(More)
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic imprinting and X-chromosome inactivation. Methylated cytosine residues at CpG dinucleotides are commonly(More)
BACKGROUND Cartilage is an avascular and aneural tissue. Chondrocytes thrive in this restricted environment of low oxygen tension and poor nutrient availability which has led to suggestions that hypoxia may be a protective mechanism against the development of osteoarthritis (OA). There is also a growing body of evidence to support the role of epigenetic(More)
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