María Belén Bouzas

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BACKGROUND The genetic differences among HIV-1 subtypes may be critical to clinical management and drug resistance surveillance as antiretroviral treatment is expanded to regions of the world where diverse non-subtype-B viruses predominate. METHODS AND FINDINGS To assess the impact of HIV-1 subtype and antiretroviral treatment on the distribution of(More)
BACKGROUND Diagnosis of primary HIV infection (PHI) has important clinical and public health implications. HAART initiation at this stage remains controversial. METHODS Our objective was to identify predictors of disease progression among Argentinean seroconverters during the first year of infection, within a multicentre registry of PHI-patients diagnosed(More)
BACKGROUND Genetic characterization of HIV-1 in Argentina has shown that BF recombinants predominate among heterosexuals and injecting drug users, while in men who have sex with men the most prevalent form is subtype B. OBJECTIVES The aim of this work was to investigate the presence of HIV dual infections in HIV-infected individuals with high probability(More)
OBJECTIVE Our objective was to estimate primary resistance in an urban setting in a developing country characterized by high antiretroviral (ARV) coverage over the diagnosed population and also by an important proportion of undiagnosed individuals, in order to determine whether any change in primary resistance occurred in the past five years. DESIGN We(More)
Hepatitis B virus (HBV) is a globally distributed human pathogen that leads to both self-limited and chronic infections. At least eight genotypes (A-H) with distinct geographical allocations and phylodynamic behaviors have been described. They differ substantially in many virological and probably some clinical parameters. The aim of this study was to(More)
HTLV-1 is currently classified in 7 different subtypes (a-g) based on the nucleotide diversity of its LTR region. The Cosmopolitan subtype (a) has spread worldwide and is further divided into 5 subgroups: Transcontinen-tal (A), Japanese (B), West African (C), North African (D) and Peruvian (E). Different clusters has been described within the subgroup a(More)
Few ATLL cases have been reported in the country, the majority of the acute leukemia subtype. HTLV-1 proviral load is considered a prognosis marker and it has been available in our setting since 2008. We present HTLV-1 proviral loads in 3 cases of ATLL received during the last 4 years. Two cases were of the acute subtype and one case of the lymphoma(More)
Mannose-binding lectin (MBL) plays an important role in the innate immune defense against invading microorganisms. Deficiency of functional MBL is linked to poly-morphisms in the MBL2 gene. The aim of the study was to determine the influence of MBL2 polymorphisms in susceptibility to HTLV-1 infection. A total of 43 HTLV-1 infected subjects and 127 healthy(More)
In order to determine HIV-1 kinetics in cerebrospinal fluid (CSF) and plasma in patients with cryptococcal meningitis (CM), we undertook a prospective collection of paired CSF/plasma samples from antiretroviral therapy-free HIV-infected patients with CM. Samples were obtained at baseline (S1) and at the second (S2) and third (S3) weeks of antifungal(More)