Learn More
Physicochemical and organoleptic characteristics of meat (longissimus muscle) from Criollo Cordobes (CC) and Anglonubian (AN) suckling kids were analysed to determine the effects of genotype and slaughter weight. Forty suckling entire male kids, 20 CC and 20 AN were assigned to two age/slaughter weight groups (I: 60+2days old and ⩽11kg, and II: 90+2days old(More)
OBJECTIVE Tissue glucocorticoid (GC) levels are regulated by the GC-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is expressed in cells and tissues arising from mesenchymal stromal cells. Proinflammatory cytokines dramatically increase expression of 11β-HSD1 in stromal cells, an effect that has been implicated in(More)
OBJECTIVES The success of B cell targeting therapies has highlighted the importance of B cells in rheumatoid arthritis pathogenesis. We have previously shown that B cells in the RA synovium are capable of producing pro-inflammatory and bone-destructive cytokines including RANKL. Here we sought to characterise the nature and functional relevance of the(More)
OBJECTIVE To investigate serum antibody reactivity against a panel of post-translationally modified vimentin peptides (PTMPs) in patients with early inflammatory arthritis. METHODS A panel of PTMPs was developed. Microtitre plates were coated with peptides derived from vimentin that were identical in length and composition except at one amino acid that(More)
INTRODUCTION Inflammatory arthritis is associated with increased bone resorption and suppressed bone formation. The Wnt antagonist dickkopf-1 (DKK1) is secreted by synovial fibroblasts in response to inflammation and this protein has been proposed to be a master regulator of bone remodelling in inflammatory arthritis. Local glucocorticoid production is also(More)
OBJECTIVE To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well-characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls. METHODS Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively(More)
It may be, however, that sarcoid of the SI joint may be more common than previously thought. A single European study found that isolated pulmonary sarcoid was associated with HLA-B27 [10], making a true association between SpA and sarcoid possible, but this finding has not been replicated and the relatively high prevalence of the two conditions (1:1000 for(More)
BACKGROUND Synovial fibroblasts play a key role in joint destruction and regulation of the inflammatory infiltrate in established rheumatoid arthritis (RA). The mechanisms by which this occurs in the earliest stages of RA are largely unknown. We investigated the role of Dickkopf-related protein 1 (DKK1) produced by synovial fibroblasts of patients with very(More)
Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis Detection of antibodies to citrullinated tenascin-C in patients with early synovitis is associated with the development of rheumatoid arthritis. Early treatment of rheumatoid arthritis (RA) results in more effective(More)
The main secondary metabolite of Senecio nutans is 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone (4HMBA). The antifungal activity of this compound and three derivatives was assessed using Candida albicans. 4HMBA exhibited the highest antifungal activity among the assayed compounds. The Fractional Inhibitory Concentration (FIC = 0.133) indicated a synergistic(More)