Maoyuan Zhao

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Lung cancer is the leading cause of cancer-related deaths worldwide, and treatments for lung cancer have a high failure rate. Anti-angiogenic therapy is also often ineffective because of refractory disease. Endostatin (ES) is one of the most widely-used anti-angiogenic drugs for lung cancer in China, and resistance to it is a barrier that needs to be(More)
OBJECTIVE Epithelial-mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-β1) is an important factor in EMT induction in tumorigenesis. The targeting of EMT may, therefore, represent a promising approach in anticancer treatment. METHODS In this study, we determined the effect of decitabine, a DNA(More)
Dear Editor: Aspirin is widely used for treatment of pain, fever, rheumatism, cardiovascular disease, and other inflammatory conditions. Recently, the prophylactic and therapeutic effects of aspirin in malignant tumors, especially in colorectal cancers (CRCs), have attracted intensive attention. Epidemiological studies had reported long-term intake of(More)
Stem cell factor (SCF) plays an important role in tumor growth and metastasis. However, the function of SCF in regulating stemness and migration of cancer stem cells (CSCs) remains largely undefined. Here, we report that non-adhesive culture system can enrich and expand CSCs derived from Lewis lung carcinoma (LLC) cells and that the expression level of SCF(More)
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