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Although genistein has chemopreventive effects in several human malignancies, including cancers of the breast, colon, and prostate, the mechanisms of action are not fully understood. Herein we report novel mechanisms whereby genistein down-regulates the MDM2 oncogene, perhaps explaining some of its anticancer activities. In a dose- and time-dependent(More)
To track the movement of a wireless capsule, a magnetic localization and orientation system is designed. In this system, a permanent magnet is enclosed in the capsule, which generates a magnetic field around. With the magnetic sensor array arranged out of the human body, we can measure the magnet's magnetic signals, and compute the capsule's 3D localization(More)
BACKGROUND Primary open-angle glaucoma (POAG) is the most common form of glaucoma which is an irreversible blind leading disease and lacks effective remedies. In recent years, POAG has been linked to the gene MYOC encoding myocilin that has been identified to harbor causal mutations. A variety of studies show that the mutant myocilin acts by gain of(More)
The oncoprotein MDM2, a major ubiquitin E3 ligase of tumor suppressor p53, has been suggested as a novel target for human cancer therapy based on its p53-dependent and p53-independent activities. We have identified curcumin, which has previously been shown to have anticancer activity, as an inhibitor of MDM2 expression. Curcumin down-regulates MDM2,(More)
PURPOSE The present study was undertaken to determine the effects of dexamethasone (DEX) pretreatment on antitumor activity and pharmacokinetics of the cancer chemotherapeutic agents carboplatin and gemcitabine. EXPERIMENTAL DESIGN Antitumor activities of carboplatin and gemcitabine with or without DEX pretreatment were determined in six murine-human(More)
In this paper, we discuss the influence of the antenna orientation radiation pattern in localization algorithm based on Received Signal Strength Indicator (RSSI). We also improve the empirical model of signal propagation by building the path loss function of the human gastro-intestine (GI) tract. The novel model includes information of both the distance and(More)
Advances in mobile computing technologies have proved an unheralded boon to mobile games developers. Increasingly, position-sensing technologies such as GPS and cellular techniques can be harnessed. This offers exciting opportunities for novel game development. However, classic board games can also be refined and extended , leading to, amongst other things,(More)
Mycoplasma, the smallest self-replicating organism with a minimal metabolism and little genomic redundancy, is expected to be a close approximation to the minimal set of genes needed to sustain bacterial life. This study employs comparative evolutionary analysis of twenty Mycoplasma genomes to gain an improved understanding of essential genes. By analyzing(More)
Whole-body computed tomography (CT) image registration is important for cancer diagnosis, therapy planning and treatment. Such registration requires accounting for large differences between source and target images caused by deformations of soft organs/tissues and articulated motion of skeletal structures. The registration algorithms relying solely on image(More)
To track the movement of a wireless capsule and get the 6D localization and orientation information of the capsule, a magnetic localization and orientation system is designed. In this system, we propose to enclose two orthogonal permanent magnets in the capsule. With the magnetic sensor array arranged out of the human body, we can measure the magnets'(More)