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Cyclodipeptides from metagenomic library of a japanese marine sponge
Culture-independent metagenomics is an attractive and promising approach to explore unique bioactive small molecules from marine sponges harboring uncultured symbiotic microbes. Therefore, weExpand
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Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia.
Naturally occurring dimeric 1,4-benzoquinone derivatives, belamcandaquinones F, G, H, and I, as well as one resorcinol derivative and four known compounds, were isolated from rhizomes of ArdisiaExpand
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Combination of artemisinin‐based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies
Currently, the most effective antimalarial is artemisinin, which is extracted from the leaves of medicinal herb Artemisia annua L. (A. annua). Previous studies showed that the complex chemical matrixExpand
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Two New Resorcinol Derivatives with Strong Cytotoxicity from the Roots of Ardisia brevicaulis Diels
Two new resorcinol derivatives, 4‐hydroxy‐2‐methoxy‐6‐[(8Z)‐pentadec‐8‐en‐1‐yl]phenyl acetate (1) and 4‐hydroxy‐2‐methoxy‐6‐pentadecylphenyl acetate (2), together with known compounds ardisiphenol DExpand
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Four New 1,4-Benzoquinone Derivatives and One New Coumarin Isolated from Ardisia gigantifolia
Four new 1,4-benzoquinone derivatives, belamcandaquinones J (1), K (2), L (3), and M (4), and one new coumarin, 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures wereExpand
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Artemisinin and Its Derivatives as a Repurposing Anticancer Agent: What Else Do We Need to Do?
Preclinical investigation and clinical experience have provided evidence on the potential anticancer effect of artemisinin and its derivatives (ARTs) in the recent two decades. The major mechanismsExpand
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Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model.
The present work seeks to construct a nanovehicle for the efficient suppression of breast cancer metastasis through targeting E-selectin on tumor vascular endothelial cells and hyaluronicExpand
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Two New Resveratrol Tetramers Isolated from Cayratia japonica (Thunb.) Gagn. with Strong Inhibitory Activity on Fatty Acid Synthase and Antioxidant Activity
Two new resveratrol tetramers, cajyphenol A (1) and cajyphenol B (2), together with two known resveratrol dimers, quadrangularin A (3) and pallidol (4), and resveratrol (5) were isolated from theExpand
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HPLC-ESI-MS/MS validation and pharmacokinetics of kalopanaxsaponin A in rats
Kalopanaxsaponin A (KPS-A) is a potential anti-tumor active compound isolated from the stems of Stauntonia obovatifoliola Hayata subsp. intermedia. A rapid and accurate high-performance liquidExpand
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Liver-targeting self-assembled hyaluronic acid-glycyrrhetinic acid micelles enhance hepato-protective effect of silybin after oral administration
Abstract In order to enhance oral bioavailability and liver targeting delivery of silybin, two amphiphilic hyaluronic acid derivatives, hyaluronic acid-deoxycholic acid (HA-adh-DOCA) and hyaluronicExpand
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