Manvinder Singh

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STUDY OBJECTIVE To determine the impact of sonographically identified large uterine fibroids (>5 cm in diameter) on obstetric outcomes. DESIGN Retrospective cohort study. SETTING University teaching hospital. PATIENT(S) Women with singleton gestations (n = 95) noted to have uterine fibroids on obstetric ultrasonography from September 2009 through(More)
Gonadotropins are a valuable part of the armamentarium available to assist couples in achieving a live birth. Multiple approaches can be used to limit the risk of multiple gestations, but with potential negative impact on establishing pregnancies. Financial considerations often limit enthusiasm for approaches which could reduce success in achieving(More)
OBJECTIVE To compare the development and implantation of human embryos biopsied with two different methods for preimplantation genetic diagnosis (PGD). DESIGN Technique and method. SETTING A regional hospital IVF laboratory and private reproductive medicine clinic. PATIENT(S) Women undergoing IVF and PGD. INTERVENTION(S) Day 3 embryos were biopsied(More)
Human first-trimester trophoblast cells proliferate at low O2, but survival is compromised by oxidative stress, leading to uteroplacental insufficiency. The vasoactive drug, sildenafil citrate (Viagra, Sigma, St Louis, Missouri), has proven useful in reducing adverse pregnancy outcomes. An important biological function of this pharmaceutical is its action(More)
BACKGROUND We present a patient with primary amenorrhea and a rare combination of anomalies. She was found to have a septate uterus, double cervix, and a longitudinal and a low transverse vaginal septum. CASE An 18-year-old girl with primary amenorrhea presented with severe monthly pelvic pain. Examination and imaging revealed a thin transverse vaginal(More)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive defect in cortisol biosynthesis that elevates fetal androgen levels to cause genital ambiguity and external genital masculinization in newborn females. Introducing dexamethasone in utero by 7 weeks gestation precludes virilization of affected females. However, identification of a male fetus(More)
OBJECTIVE To determine the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on trophoblast invasiveness. DESIGN Laboratory investigation. SETTING Academic medical center. PATIENT(S) Placental tissues discarded after first-trimester terminations were obtained from patients with informed consent. INTERVENTION(S) A cell line, HTR-8/SVneo,(More)
BACKGROUND Currently, there is no agreement on the optimal urinary derived human chorionic gonadotropin (u-hCG) dose requirement for initiating final oocyte maturation prior to oocyte collection in in vitro fertilization (IVF), but doses that range from 2500- 15000 IU have been used. We intended to determine whether low dose u-hCG was effective for oocyte(More)
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