Manvinder Singh

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STUDY OBJECTIVE To determine the impact of sonographically identified large uterine fibroids (>5 cm in diameter) on obstetric outcomes. DESIGN Retrospective cohort study. SETTING University teaching hospital. PATIENT(S) Women with singleton gestations (n = 95) noted to have uterine fibroids on obstetric ultrasonography from September 2009 through(More)
Human first-trimester trophoblast cells proliferate at low O2, but survival is compromised by oxidative stress, leading to uteroplacental insufficiency. The vasoactive drug, sildenafil citrate (Viagra, Sigma, St Louis, Missouri), has proven useful in reducing adverse pregnancy outcomes. An important biological function of this pharmaceutical is its action(More)
Aristotle provides program analysis information, and supports the development of software engineering tools. Aristotle's front end consists of parsers that gather control flow, local dataflow and symbol table information for procedural language programs. We implemented a parser for C by incorporating analysis routines into the GNU C parser; a C++ parser is(More)
Gonadotropins are a valuable part of the armamentarium available to assist couples in achieving a live birth. Multiple approaches can be used to limit the risk of multiple gestations, but with potential negative impact on establishing pregnancies. Financial considerations often limit enthusiasm for approaches which could reduce success in achieving(More)
OBJECTIVE To compare the development and implantation of human embryos biopsied with two different methods for preimplantation genetic diagnosis (PGD). DESIGN Technique and method. SETTING A regional hospital IVF laboratory and private reproductive medicine clinic. PATIENT(S) Women undergoing IVF and PGD. INTERVENTION(S) Day 3 embryos were biopsied(More)
However, the article also highlighted the company’s most daunting challenge. Many of the company’s core brands were maturing. While top-line growth had been sustained comfortably in the double digit range through the early and mid 1990s, it had declined to 7%, 5%, and 4% in 1999, 2000, and 2001. As a result, managerial staff at all levels had been(More)
BACKGROUND We present a patient with primary amenorrhea and a rare combination of anomalies. She was found to have a septate uterus, double cervix, and a longitudinal and a low transverse vaginal septum. CASE An 18-year-old girl with primary amenorrhea presented with severe monthly pelvic pain. Examination and imaging revealed a thin transverse vaginal(More)
OBJECTIVE To determine the effect of sildenafil, a phosphodiesterase type 5 inhibitor, on trophoblast invasiveness. DESIGN Laboratory investigation. SETTING Academic medical center. PATIENT(S) Placental tissues discarded after first-trimester terminations were obtained from patients with informed consent. INTERVENTION(S) A cell line, HTR-8/SVneo,(More)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive defect in cortisol biosynthesis that elevates fetal androgen levels to cause genital ambiguity and external genital masculinization in newborn females. Introducing dexamethasone in utero by 7 weeks gestation precludes virilization of affected females. However, identification of a male fetus(More)
BACKGROUND Currently, there is no agreement on the optimal urinary derived human chorionic gonadotropin (u-hCG) dose requirement for initiating final oocyte maturation prior to oocyte collection in in vitro fertilization (IVF), but doses that range from 2500- 15000 IU have been used. We intended to determine whether low dose u-hCG was effective for oocyte(More)
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