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Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content
Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basisExpand
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Genetic Elements Carrying erm(B) in Streptococcus pyogenes and Association with tet(M) Tetracycline Resistance Gene
ABSTRACT This study was directed at characterizing the genetic elements carrying the methylase gene erm(B), encoding ribosome modification-mediated resistance to macrolide, lincosamide, andExpand
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New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci.
OBJECTIVES To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci. METHODS Sixteen Streptococcus pneumoniaeExpand
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The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggestingExpand
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Molecular Characterization of Pneumococci with Efflux-Mediated Erythromycin Resistance and Identification of a Novel mef Gene Subclass, mef(I)
ABSTRACT The molecular genetics of macrolide resistance were analyzed in 49 clinical pneumococci (including an “atypical” bile-insoluble strain currently assigned to the new species StreptococcusExpand
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Prophage association of mef(A) elements encoding efflux-mediated erythromycin resistance in Streptococcus pyogenes.
OBJECTIVES To compare different mef(A) elements of Streptococcus pyogenes for a possible chimeric genetic nature, i.e. a transposon inserted into a prophage. METHODS Eleven S. pyogenes isolatesExpand
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Composite Structure of Streptococcus pneumoniae Containing the Erythromycin Efflux Resistance Gene mef(I) and the Chloramphenicol Resistance Gene catQ
ABSTRACT In recent years mef genes, encoding efflux pumps responsible for M-type macrolide resistance, have been investigated extensively for streptococci. mef(I) is a recently described mef variantExpand
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The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation Rossella Lucá1,2y, Michele Averna1,2y, Francesca Zalfa3,4y, Manuela Vecchi5,6y, Fabrizio Bianchi,Expand
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Analysis of the functional relationship between V3 loop and gp120 context with regard to human immunodeficiency virus coreceptor usage using naturally selected sequences and different viral backbones.
The human immunodeficiency virus type 1 (HIV-1) gp120 V3 loop plays a predominant role in chemokine receptor usage; however, other linear and nonlinear gp120 domains are involved in this step of theExpand
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The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function
The F‐box protein FBXW7 is the substrate‐recruiting subunit of an SCF ubiquitin ligase and a major tumor‐suppressor protein that is altered in several human malignancies. Loss of function of FBXW7Expand
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