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Overexpression of PAK1 Promotes Cell Survival in Inflammatory Bowel Diseases and Colitis-associated Cancer
Background:Chronic gut inflammation predisposes to the development of colorectal cancer and increased mortality. Use of mesalamine (5-ASA) in the treatment of ulcerative colitis modulates the risk ofExpand
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Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
BackgroundPatients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancerExpand
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IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis
Colon cancers exhibit an increased IL22:IL10 ratio. The two cytokines share one receptor subunit, but their second receptor subunits are distinct. Colorectal cancer shows overexpression of bothExpand
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Increased expression of HIF2α during iron deficiency–associated megakaryocytic differentiation
Iron deficiency is associated with reactive thrombocytosis; however, the mechanisms driving this phenomenon remain unclear. We previously demonstrated that this occurs alongside enhancedExpand
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PWE-014 Iron therapy and its effect on cell proliferation in human colorectal carcinoma
Introduction Oral iron (but not intravenous iron) promotes intestinal tumourigenesis in animal models [1]. This is the first study to examine the effect of iron therapy on proliferation and apoptosisExpand
Abstract 3712: p21-activated kinase-1 in the prevention of inflammation-driven colon cancer.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Chronic gut inflammation in inflammatory bowel diseases (IBD) predisposes to the development of colorectal cancer, causingExpand
PWE-013 The effects of iron therapy on iron transport in human colorectal cancer
Introduction Iron is essential for the proliferation of all mammalian cells. We previously showed that the expression of iron transport proteins are altered in colorectal cancer (CRC) [1]. This isExpand