Manuela Castilla

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BACKGROUND Cilastatin reduces nephrotoxicity associated with cyclosporin A (CyA) in solid organ and bone marrow transplantation. This appears to be unrelated to changes in renal haemodynamics or CyA metabolism. How cilastatin induces this protection is unclear, but it could result from changes on accumulation of CyA proximal cells. METHODS We investigated(More)
P"rpse: To investigate the clinical and histological toxicity of the exposure of the :rabbit cornea1 endothelium to anterior chamber injection of liposome-encapsulated 5-fluorouridine (LS-FUR) at concentrations of 1 mg/ml and 0.38 mg/ml and intravitreal injection of I.5FUR at 1 mg/ml. M*thOdS : A total of 12 New Zealand white rabbits were divided in three(More)
Pm: A new hydrogel composed ofiota-carrageenan/polyvinylpyrrolidon (i-cgn/pvp) was tested in rabbit eyes to dctennine its intraocular tolerance and to evaluate its suitability as a vitreous substitute. MefhodF: Aver pars-plana lensectomy and pars-plana vitrectomy 1,Sml of i-cgn/pvp were injected into 4 eyes of 4 rabbitsThe untreated contralateral eyd served(More)
PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2)(More)
PURPOSE the autors study the results of the PCR, the C coefficient and the Ig A antibodies of 30 patients without toxoplasmosis. METHODS An anterior chamber puncture is operated on 30 patients undergoing cataract surgery. RESULTS Contrary to all expectations, some of the results tend towards evolutional toxoplasmosis. CONCLUSION The interest of these(More)
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