Manuela Capillo

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Acute promyelocytic leukemia (APL) is associated with chromosomal translocations resulting in fusion proteins of the retinoic acid receptor (RAR). Here, we report a novel murine model system for APL, based on the transduction of purified murine hematopoietic progenitors (lin(-)) using high-titer retroviral vectors encoding promyelocytic leukemia-RAR(More)
retroviral gene transfer into purified murine hematopoietic progenitors PML-RAR induces promyelocytic leukemias with high efficiency following Information about subscriptions and ASH membership may be found online at:. Abstract Acute Promyelocytic Leukemia (APL) is associated with chromosomal translocations resulting in fusion proteins of the retinoic acid(More)
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