Manuela Buzoianu

Learn More
BACKGROUND Targeting the cell-surface receptor EphA2, which is highly expressed in some solid tumors, is a novel approach for cancer therapy. We aimed to evaluate the safety profile, maximum tolerated dose (MTD), pharmacokinetics, and antitumor activity of MEDI-547, an antibody drug conjugate composed of the cytotoxic drug auristatin (toxin) linked to a(More)
PURPOSE Clinical development of cancer drugs has a low success rate. Prognostic and predictive biomarkers using minimally invasive approaches hold promise for increasing the probability of success by enabling disease characterization, patient selection and early detection of drug treatment effect. Enumeration and molecular characterization of circulating(More)
We introduce a new model for electricity prices, based on the principle of supply and demand equilibrium. The model includes latent supply and demand curves, which may vary over time, and assumes that observed price/quantity pairs are obtained as the intersection of the two curves, for any particular point in time. Although the model is highly nonlinear, we(More)
  • 1