Manuel Villén-Altamirano

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RESTART (Repetitive Simulation Trials After Reaching Thresholds) is a widely applicable accelerated simulation technique that allows the evaluation of extremely low probabilities. The focus of this article is on providing guidelines for achieving a high efficiency in a simulation with RESTART. Emphasis is placed on the choice of the importance function,(More)
This paper is a tutorial on RESTART, a widely applicable accelerated simulation technique for estimating rare event probabilities. The method is based on performing a number of simulation retrials when the process enters regions of the state space where the chance of occurrence of the rare event is higher. The paper analyzes its efficiency, showing formulas(More)
This paper is a tutorial on RESTART, a widely applicable accelerated simulation technique for estimating rare event probabilities. The method is based on performing a number of simulation retrials when the process enters regions of the state space where the chance of occurrence of the rare event is higher. The paper analyzes its efficiency, showing formulas(More)
The last decade has witnessed significant developments in various aspects of Biomedical Informatics, including Bioinformatics, Medical Informatics, Public Health Informatics, and Biomedical Imaging. The explosion of medical and biological data requires an associated increase in the scale and sophistication of the automated systems and intelligent tools to(More)