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A gating mechanism of pentameric ligand-gated ion channels.

• Nicolas Calimet, Manuel Sobrinho Simões, Jean-Pierre Changeux, Martin Karplus, Antoine Taly, Marco Cecchini
• Proceedings of the National Academy of Sciences…
• 2013

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communication in the nervous system and are involved in fundamental processes such as attention, learning, and… (More)

Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.

• Yolaine Dodier, Umberto Banderali, +6 authors Lucie Parent
• The Journal of biological chemistry
• 2004

The substituted cysteine accessibility method (SCAM) was used to map the external vestibule and the pore region of the ECaC-TRPV5 calcium-selective channel. Cysteine residues were introduced at 44… (More)

The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.

• Alexandra Raybaud, Yolaine Dodier, +4 authors Lucie Parent
• The Journal of biological chemistry
• 2006

The putative hinge point revealed by the crystal structure of the MthK potassium channel is a glycine residue that is conserved in many ion channels. In high voltage-activated (HVA) Ca(V) channels,… (More)

A single residue in the S6 transmembrane domain governs the differential flecainide sensitivity of voltage-gated potassium channels.

• Daniel Herrera, Aida M. Mamarbachi, +4 authors Stanley Nattel
• Molecular pharmacology
• 2005

Flecainide has been used to differentiate Kv4.2-based transient-outward K(+)-currents (flecainide-sensitive) from Kv1.4-based (flecainide-insensitive). We found that flecainide also inhibits… (More)

Structural Determinants of the Closed KCa3.1 Channel Pore in Relation to Channel Gating: Results from a Substituted Cysteine Accessibility Analysis

• Hélène Klein, L. François-Xavier Garneau, Umberto Banderali, Manuel Sobrinho Simões, Lucie Parent, Rémy Sauvé
• The Journal of general physiology
• 2007

In this work we address the question of the KCa3.1 channel pore structure in the closed configuration in relation to the contribution of the C-terminal end of the S6 segments to the Ca(2+)-dependent… (More)

Cysteine Mutagenesis and Computer Modeling of the S6 Region of an Intermediate Conductance IKCa Channel

• Manuel Sobrinho Simões, L. François-Xavier Garneau, +5 authors Rémy Sauvé
• The Journal of general physiology
• 2002

Cysteine-scanning mutagenesis (SCAM) and computer-based modeling were used to investigate key structural features of the S6 transmembrane segment of the calcium-activated K(+) channel of intermediate… (More)

New Insights on the Voltage Dependence of the KCa3.1 Channel Block by Internal TBA

• Umberto Banderali, Hélène Klein, L. François-Xavier Garneau, Manuel Sobrinho Simões, Lucie Parent, Rémy Sauvé
• The Journal of general physiology
• 2004

We present in this work a structural model of the open IKCa (KCa3.1) channel derived by homology modeling from the MthK channel structure, and used this model to compute the transmembrane potential… (More)

A Clinical Case Report of Cribriform-Morular Variant of Papillary Thyroid Carcinoma with Neuroendocrine Differentiation and Aggressive Behaviour in a Patient with Familial Adenomatous Polyposis Coli

• Rovel J Colaco, Lia Patricia Menasce, +4 authors Beng Khiong Yap
• 2009

Cribriform-morular variant of papillary thyroid carcinoma (CMVPTC) is a rare variant of papillary thyroid cancer mostly occurring in young females under the age of 30. CMVPTC is associated with… (More)

Health Science Research: The Role of Translation

• Manuel Sobrinho Simões
• 2012

Europath News

• Manuel Sobrinho Simões
• Virchows Archiv
• 2000

We are very pleased to convey to you the fourth issue of our ESP Newsletter. This issue begins with the Presidential address of Prof. Manuel Sobrinho Simoes. Following this, a summary of the minutes… (More)

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