Manuel S Dumlao

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1. Animal and human studies suggest a possible relationship between dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and cognitive impairment. 2. In animals, prolonged exposure to high plasma cortisol levels causes irreversible hippocampal damage. 3. Abnormal cortisol plasma levels in response to dexamethasone challenge have been frequently(More)
The present study evaluates the relationship between brain-adrenal axis activity and cognitive function in patients suffering from senile dementia of the Alzheimer's type (SDAT). Thirty-four subjects (20 females and 14 males) were assessed using the Global Deterioration Scale (GDS) and plasma cortisol levels after administration of 0.5 mg of dexamethasone.(More)
Previous studies show an association between increased plasma cortisol levels and aging, a process which is also associated with some deterioration of cognition. Animal studies demonstrated damage to pyramidal cells in the hippocampus, secondary to increased cortisol secretion. Conditions in which high cortisol plasma levels are encountered suggest an(More)
Depression is a major health issue among older adults receiving home-based services yet is underdiagnosed and undertreated, which can result in negative health outcomes. Despite the recognized need for improved mental health services, significant gaps and barriers exist that contribute to less than optimal home-based depression management interventions.(More)
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