Manuel Rodrigo

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Targeting therapeutic genes to the liver is essential to improve gene therapy protocols of hepatic diseases and of some hereditary disorders. Transcriptional targeting can be achieved using liver-specific promoters. In this study we have made chimeric constructs combining promoter and enhancer regions of the albumin, alpha 1-antitrypsin, hepatitis B virus(More)
Variable optical carrier reduction via the use of a Si(3)N(4) ring resonator notch filter with tunable extinction ratio is demonstrated in a 10 GHz radio-over-fiber system for improving the modulation efficiency. The extinction of the filter notch is tuned with micro-heaters, by setting the Mach-Zehnder coupler of the ring. Experimental results showing a(More)
Combining photonic integrated circuits with a biologically based sensing approach has the ability to provide a new generation of portable and low-cost sensor devices with a high specificity and sensitivity for a number of applications in environmental monitoring, defense, and homeland security. We report herein on the specific biosensing under continuous(More)
While there have been huge advances in the field of biosensors during the last decade, their integration into a microfluidic environment avoiding external tubing and pumping is still neglected. Herein, we show a new microfluidic design that integrates multiple reservoirs for reagent storage and single-use electrochemical pumps for time-controlled delivery(More)
In this work, we present integrated photonic sensor design to detect Chemical, Biological, Radiological and Nuclear (CBRN) threats, where high sensitivity and no false positive are strictly required. The sensor is formed by several parallel micro-ring resonators exposed to the environment and functionalized to recognized target analytes in a free-label way.(More)
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