Manuel Rodríguez Álvarez

Learn More
Biosensors based on microcantilevers have become a promising tool for directly detecting biomolecular interactions with great accuracy. Microcantilevers translate molecular recognition of biomolecules into nanomechanical motion that is commonly coupled to an optical or piezoresistive read-out detector system. Biosensors based on cantilevers are a good(More)
We have proposed various procedures that are based on geometrical properties of source vectors, S (t), and of mixtures, E(t), from the hypothesis that the sources are bounded [3,4], since the real signals (speech, biomedical) are limited in amplitude. The present paper aims to extend this method to a type of nonlinear mixture that approximately models the(More)
In many Signal Processing applications, data sampled by sensors comprise a mixture of signals from different sources. The problem of separation lies in the reconstruction of sources from the mixtures. In this paper a new method is proposed for the separation of mixed digital sources, based on geometrical considerations, which is applied to the separation of(More)
A new DNA biosensor microsystem based on nanomechanical transducers is being developed. The microsystem comprises an array of 20 cantilevers, a microfludic system for delivery of the samples, an array of 20 lasers (VSCELs) and chips with the photodetectors and the CMOS circuitry for signal acquisition and conditioning. Robust immobilization procedures for(More)
A 28-year-old girl had been diagnosed as having a late juvenile form of metachromatic leukodystrophy at the age of 22 years. Her mother recalled delay in motor milestones, unstable gait in childhood and progressive difficulty in climbing stairs. At 13 years of age, the patient was unable to follow classes owing to problems in concentration and maintain-ing(More)